About: Crystallographic study of an anti=carbonic anhydrase IX monoclonal antibody M75.

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About: Crystallographic study of an anti=carbonic anhydrase IX monoclonal antibody M75. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Carbonic anhydrase IX (CA IX) is a cell surface protein, strongly associated with certain types of human carcinomas. Structural study of a CA IX-binding monoclonal antibody (mAb) M75, complexed with its epitope peptide may contribute toward elucidation of the role of CA IX. Monoclonal antibody M75 was obtained and proved to react excellently with native and denaturated CA IX. Using synthetic oligopeptides, the epitope of mAb M75 was localized in the proteoglycan domain of CA IX, in the region of a tandem repeat and identified as amino acids PGEEDLP. The Fab fragment was obtained by papain cleavage. We obtained crystals of free Fab M75 and Fab M75 complexed with two different epitope peptides. The data set for Fab M75 was collected and the structure solving is underway. Carbonic anhydrase IX (CA IX) is a cell surface protein, strongly associated with certain types of human carcinomas. Structural study of a CA IX-binding monoclonal antibody (mAb) M75, complexed with its epitope peptide may contribute toward elucidation of the role of CA IX. Monoclonal antibody M75 was obtained and proved to react excellently with native and denaturated CA IX. Using synthetic oligopeptides, the epitope of mAb M75 was localized in the proteoglycan domain of CA IX, in the region of a tandem repeat and identified as amino acids PGEEDLP. The Fab fragment was obtained by papain cleavage. We obtained crystals of free Fab M75 and Fab M75 complexed with two different epitope peptides. The data set for Fab M75 was collected and the structure solving is underway. (en)
Title	Crystallographic study of an anti=carbonic anhydrase IX monoclonal antibody M75. Crystallographic study of an anti=carbonic anhydrase IX monoclonal antibody M75. (en)
skos:prefLabel	Crystallographic study of an anti=carbonic anhydrase IX monoclonal antibody M75. Crystallographic study of an anti=carbonic anhydrase IX monoclonal antibody M75. (en)
skos:notation	RIV/68378050:_____/03:23033033!RIV/2004/AV0/A23004/N
http://linked.open.../vavai/riv/strany	70
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z5052915)
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Závadová, Zuzana Štouračová, Renata Brynda, Jiří Závada, Jan Hořejší, Magdalena Král, Vlastimil Fábry, Milan Sedláček, Juraj
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	602450
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/03:23033033
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	anti-carbonic ahydrase antibody, cancer, crystallization (en)
http://linked.open.../riv/klicoveSlovo	anti-carbonic ahydrase antibody cancer crystallization
http://linked.open...ontrolniKodProRIV	[E49B423F6E4A]
http://linked.open...v/mistoKonaniAkce	Nové Hrady [CZ]
http://linked.open...i/riv/mistoVydani	Praha, Česká republika
http://linked.open...i/riv/nazevZdroje	Material Structure in Chemistry, Biology, Physics and Technology.
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2003
http://linked.open...iv/tvurceVysledku	Brynda, Jiří Fábry, Milan Král, Vlastimil Sedláček, Juraj Závada, Jan Závadová, Zuzana Pastoreková, S. Hořejší, Magda Štouračová, Renata
http://linked.open...vavai/riv/typAkce	CST - Celostátní
http://linked.open.../riv/zahajeniAkce	2003-03-13 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Czech and Slovak Crystallographic Association

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