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| rdf:type
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| Description
| - Here we investigated whether the CpG methylation of the HIV-1 promoter can directly influence the expression of the HIV-1 genome and thereby contribute to the persistence and latency of HIV-1. The levels of CpG methylation in the promoter of HIV-1 were studied after bisulfite-induced modification of DNA in five Jurkat clonal cell lines transduced by an HIV-1 long terminal repeat (LTR)-driven retroviral vector and expressing enhanced green fluorescent protein (GFP) and in primary resting memory T cells challenged with HIV-1 or with an HIV-1-derived retroviral vector. Our results show that the methylation profiles of the HIV-1 LTR, including those present in latently infected cells, are low and do not correlate with the transcriptional activity
- Here we investigated whether the CpG methylation of the HIV-1 promoter can directly influence the expression of the HIV-1 genome and thereby contribute to the persistence and latency of HIV-1. The levels of CpG methylation in the promoter of HIV-1 were studied after bisulfite-induced modification of DNA in five Jurkat clonal cell lines transduced by an HIV-1 long terminal repeat (LTR)-driven retroviral vector and expressing enhanced green fluorescent protein (GFP) and in primary resting memory T cells challenged with HIV-1 or with an HIV-1-derived retroviral vector. Our results show that the methylation profiles of the HIV-1 LTR, including those present in latently infected cells, are low and do not correlate with the transcriptional activity (en)
- Zkoumali jsme zde, zda CpG metylace promotoru HIV-1 může přímo ovlivnit expresi genomu HIV-1 a tím přispět k perzistenci a latenci HIV-1. Úrovně CpG metylace v promotoru HIV-1 byly sledovány po modifikaci DNA vyvolané bisulfitem v pěti klonálních liniích buněk Jurkat transdukovaných vektorem regulovaným dlouhou koncovou repeticí (LTR) HIV-1 a exprimujících zelený fluorescenční protein (GFP) a v primárních klidových T buňkách vystavených působení HIV-1 či retrovirového vektoru odvozeného z HIV-1. Naše výsledky ukazují, že metylační profily HIV-1 LTR, včetně těch nacházejících se v latentně infikovaných buňkách, jsou nízké a neodpovídají transkripční aktivitě (cs)
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| Title
| - Transkripční suprese viru lidské imunodeficience typu 1 integrovaného in vitro neodpovídá metylaci provirové DNA (cs)
- Transcriptional suppression of in vitro-integrated human immunodeficiency virus type 1 does not correlate with proviral DNA methylation
- Transcriptional suppression of in vitro-integrated human immunodeficiency virus type 1 does not correlate with proviral DNA methylation (en)
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| skos:prefLabel
| - Transkripční suprese viru lidské imunodeficience typu 1 integrovaného in vitro neodpovídá metylaci provirové DNA (cs)
- Transcriptional suppression of in vitro-integrated human immunodeficiency virus type 1 does not correlate with proviral DNA methylation
- Transcriptional suppression of in vitro-integrated human immunodeficiency virus type 1 does not correlate with proviral DNA methylation (en)
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| skos:notation
| - RIV/68378050:_____/03:00108996!RIV/2005/AV0/A23005/N
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA204/01/0632), Z(AV0Z5052915)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/03:00108996
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - HIV-1 latency; transcriptional suppression; proviral CpG methylation (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Hejnar, Jiří
- Hirsch, I.
- Pion, M.
- Gondois-Rey, F.
- Verdin, E.
- Biancotto, A.
- Vigne, R.
- Dequiedt, F.
- Jordan, A.
- Rondeau, S.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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