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rdf:type
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Description
| - The monoclonal antibody 1696, which was raised against the HIV-1 protease, inhibits the catalytic activity of the enzyme from both the HIV-1 and HIV-2 strains. The antibody cross-reacts with peptides containing the N-terminus of the enzyme, which is highly conserved between these strains. The crystal structure of a single-chain Fv fragment of the previously reported non-complexed Fab-1696 and antigen-bound scFv-1696 structures. Large conformational changes in the third hypervariable region of the heavy chain and differences in relative orientation of the variable domains are observed between the different structures
- The monoclonal antibody 1696, which was raised against the HIV-1 protease, inhibits the catalytic activity of the enzyme from both the HIV-1 and HIV-2 strains. The antibody cross-reacts with peptides containing the N-terminus of the enzyme, which is highly conserved between these strains. The crystal structure of a single-chain Fv fragment of the previously reported non-complexed Fab-1696 and antigen-bound scFv-1696 structures. Large conformational changes in the third hypervariable region of the heavy chain and differences in relative orientation of the variable domains are observed between the different structures (en)
- Monoklonální protilátka 1696, která byla připravena proti proteáze HIV-1, potlačuje katalytickou aktivitu enzymu z obou kmenů HIV-1 i HIV-2. Tato protilátka křížově reaguje s peptidy obsahující N-konec enzymu, který je mezi těmito dvěma kmeny vysoce konzervován. Je popsána krystalová struktura jednořetězcového fragmentu Fv dříve popsaného nekomplexovaného Fab-1696 a struktur scFv-1696 vázaných na protilátku. Jsou pozorovány rozsáhlé konformační změny ve třetí hypervariabilní oblasti těžkého řetězce a rozdíly v relativní orientaci variabilních domén u těchto různých struktur (cs)
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Title
| - Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases
- Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases (en)
- Struktura jednořetězcového fragmentu Fv, který inhibuje proteázy HIV-1 a HIV-2 (cs)
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skos:prefLabel
| - Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases
- Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases (en)
- Struktura jednořetězcového fragmentu Fv, který inhibuje proteázy HIV-1 a HIV-2 (cs)
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skos:notation
| - RIV/68378050:_____/03:00108977!RIV/2005/AV0/A23005/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GV203/98/K023), Z(AV0Z5052915)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/03:00108977
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Acta Crystallographica Section D-Biological Crystallography
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brynda, Jiří
- Fábry, Milan
- Řezáčová, Pavlína
- Sedláček, Juraj
- Hořejší, Magdalena
- Bentley, G. A.
- Lescar, J.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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