About: Structure of a HIV-1 Protease-Inhibitor Complex determined at 1.1A resolution.

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About: Structure of a HIV-1 Protease-Inhibitor Complex determined at 1.1A resolution. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Crystallization conditions for an HIV-1 protease-inhibitor complwx were optimized to produce superior crystals for X-ray diffraction experiments. The X-ray structure of the HIV-1 protease complex was solved and regined at 1.16 A resoluton. In contrast to Saquinavir, the minetic hydroxy group of the inhibitor Z-Pns-Phe-Glu-Glu-NH2 is placed asymmetrically with respect to the non-ctystallographic twofold axis of the protease dimer so that hydrogen bonds between the carbonyl group of the inhibitor and the catalytic aspartates can be formed. The inhibitor binds in the centre of the active site by a compact network of hydrogen bonds to Gly1027, Gly2027, Asp 1025, Asp2025 and via the buried water molecule W7001 to lle 1050 and lle2050. Factors contributing to unusually high, 1.16 a, resolution (e.g. new crystal packing, binding of second molecule of Z-Pns-Phe-Glu-Glu-Nh2, etc.) will discussed. Crystallization conditions for an HIV-1 protease-inhibitor complwx were optimized to produce superior crystals for X-ray diffraction experiments. The X-ray structure of the HIV-1 protease complex was solved and regined at 1.16 A resoluton. In contrast to Saquinavir, the minetic hydroxy group of the inhibitor Z-Pns-Phe-Glu-Glu-NH2 is placed asymmetrically with respect to the non-ctystallographic twofold axis of the protease dimer so that hydrogen bonds between the carbonyl group of the inhibitor and the catalytic aspartates can be formed. The inhibitor binds in the centre of the active site by a compact network of hydrogen bonds to Gly1027, Gly2027, Asp 1025, Asp2025 and via the buried water molecule W7001 to lle 1050 and lle2050. Factors contributing to unusually high, 1.16 a, resolution (e.g. new crystal packing, binding of second molecule of Z-Pns-Phe-Glu-Glu-Nh2, etc.) will discussed. (en)
Title	Structure of a HIV-1 Protease-Inhibitor Complex determined at 1.1A resolution. Structure of a HIV-1 Protease-Inhibitor Complex determined at 1.1A resolution. (en)
skos:prefLabel	Structure of a HIV-1 Protease-Inhibitor Complex determined at 1.1A resolution. Structure of a HIV-1 Protease-Inhibitor Complex determined at 1.1A resolution. (en)
skos:notation	RIV/68378050:_____/02:23033203!RIV/2004/AV0/A23004/N
http://linked.open.../vavai/riv/strany	X1-X5
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z4055905), Z(AV0Z5052915)
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Štouračová, Renata Řezáčová, Pavlína Brynda, Jiří Fábry, Milan Sedláček, Juraj
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	665473
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/02:23033203
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Structure of a HIV-1; protease; Inhibitor complex (en)
http://linked.open.../riv/klicoveSlovo	protease Inhibitor complex Structure of a HIV-1
http://linked.open...ontrolniKodProRIV	[C4911A6D3528]
http://linked.open...v/mistoKonaniAkce	Jena, Německo [DE]
http://linked.open...i/riv/mistoVydani	Jena
http://linked.open...i/riv/nazevZdroje	9th International Conference on the crystallization of Biological Macromolecules.
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2002
http://linked.open...iv/tvurceVysledku	Brynda, Jiří Fábry, Milan Konvalinka, Jan Řezáčová, Pavlína Souček, Milan Sedláček, Juraj Hradílek, Martin Štouračová, Renata
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2002-03-23 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Chemical principles of selected biological phenomena in medicine and ecology Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Jena

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