About: Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice.

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About: Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The strain BALB/cHeA (BALB/c) is a high producer, and STS/A (STS) a low producer of IgE after Leishmania major infection. We analyzed this strain difference using 20 recombinant congenic (RC) BALB/c-c-STS/Dem (CcS/Dem) strains that carry different random subsets of 12.5% of genes of the strain STS on the BALB/c background. Strains CcS-16 and -20 exhibit a high and a low IgE level, respectively. In their F, hybrids with BALBIc we mapped nine Leishmania major response (Lmr) loci. Two of them we previously found to influence IgE level in CcS-5. IgE production in CcS-16 is controlled by loci on chromosomes 2, 10, 16 and 18 and in CcS-20 by loci on chromosomes 1, 3, 4, 5 and 8. The STS alleles of loci on chromosomes 1, 4, 5, 8 and 10 were associated with a low, whereas the STS alleles on chromosomes 16 and 18 with a high IgE production. The loci on chromosomes 2 and 3 have no apparent individual effect, but interact with the loci on chromosomes 10 and 1, respectively. The loci on chromosomes 10 and 18 were The strain BALB/cHeA (BALB/c) is a high producer, and STS/A (STS) a low producer of IgE after Leishmania major infection. We analyzed this strain difference using 20 recombinant congenic (RC) BALB/c-c-STS/Dem (CcS/Dem) strains that carry different random subsets of 12.5% of genes of the strain STS on the BALB/c background. Strains CcS-16 and -20 exhibit a high and a low IgE level, respectively. In their F, hybrids with BALBIc we mapped nine Leishmania major response (Lmr) loci. Two of them we previously found to influence IgE level in CcS-5. IgE production in CcS-16 is controlled by loci on chromosomes 2, 10, 16 and 18 and in CcS-20 by loci on chromosomes 1, 3, 4, 5 and 8. The STS alleles of loci on chromosomes 1, 4, 5, 8 and 10 were associated with a low, whereas the STS alleles on chromosomes 16 and 18 with a high IgE production. The loci on chromosomes 2 and 3 have no apparent individual effect, but interact with the loci on chromosomes 10 and 1, respectively. The loci on chromosomes 10 and 18 were (en)
Title	Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice. Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice. (en)
skos:prefLabel	Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice. Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice. (en)
skos:notation	RIV/68378050:_____/02:23033175!RIV/2004/AV0/A23004/N
http://linked.open.../vavai/riv/strany	187;195
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA310/00/0760), P(NM28), P(OK 394), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Vojtíšková, Jarmila Lipoldová, Marie Havelková, Helena Pilčík, Tomáš Vladimirov, Vladimir
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	663318
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/02:23033175
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	IgE; quantitative trait; Leishmania major, (en)
http://linked.open.../riv/klicoveSlovo	IgE Leishmania major quantitative trait
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[7CDE30B6C276]
http://linked.open...i/riv/nazevZdroje	Genes and immunity
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Genetic analysis of immune response Genetic regulation of IgE expression - implications for human atopic diseases http://linked.opendata.cz/resource/domain/vavai/projekt/OK%20394
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	2002
http://linked.open...iv/tvurceVysledku	Volf, P. Demant, P. Havelková, Helena Lipoldová, Marie Svobodová, M. Vojtíšková, Jarmila Pilčík, Tomáš Bádalová, J. Engová, J. Vladimirov, Vladimir
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	1466-4879
number of pages	9 (xsd:int)

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