About: Apoptosis induction by iron deprivation in tumor cells: role of mitochondria and caspases.

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About: Apoptosis induction by iron deprivation in tumor cells: role of mitochondria and caspases. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Iron deprivation specifically induces apoptosis in some tumor cells while other tumor cells are resistant. We have shown previously that the p53 pathway, including p53 activation and subsequent regulation of the expression of relevant genes of the bcl-2 family such as bax and bcl-2, is not involved in apoptosis induction by iron deprivation. In the present study we compared the activity of caspase-3 and caspase-9 in sensitive (38C13) versus resistant (EL4) cells under control and iron-depriving conditions. Iron deprivation resulted in a significant increase of the caspase-3 activity in sensitive but not in resistant cells. Similarly, we detected caspase-9 activation under iron deprivation in sensitive but not in resistant cells. We also compared the distribution of some proteins of the Bcl-2 family in sensitive versus resistant cells under control and iron-depriving conditions. Confocal microscopy revealed that iron deprivation resulted in Bax protein translocation from the cytosol to mitochondria in Iron deprivation specifically induces apoptosis in some tumor cells while other tumor cells are resistant. We have shown previously that the p53 pathway, including p53 activation and subsequent regulation of the expression of relevant genes of the bcl-2 family such as bax and bcl-2, is not involved in apoptosis induction by iron deprivation. In the present study we compared the activity of caspase-3 and caspase-9 in sensitive (38C13) versus resistant (EL4) cells under control and iron-depriving conditions. Iron deprivation resulted in a significant increase of the caspase-3 activity in sensitive but not in resistant cells. Similarly, we detected caspase-9 activation under iron deprivation in sensitive but not in resistant cells. We also compared the distribution of some proteins of the Bcl-2 family in sensitive versus resistant cells under control and iron-depriving conditions. Confocal microscopy revealed that iron deprivation resulted in Bax protein translocation from the cytosol to mitochondria in (en)
Title	Apoptosis induction by iron deprivation in tumor cells: role of mitochondria and caspases. Apoptosis induction by iron deprivation in tumor cells: role of mitochondria and caspases. (en)
skos:prefLabel	Apoptosis induction by iron deprivation in tumor cells: role of mitochondria and caspases. Apoptosis induction by iron deprivation in tumor cells: role of mitochondria and caspases. (en)
skos:notation	RIV/68378050:_____/02:23033137!RIV/2004/AV0/A23004/N
http://linked.open.../vavai/riv/strany	2
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z5052915)
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Kovář, Jan Koc, Michal Truksa, Jaroslav Štýbrová, Hana Ehrlichová, Marie
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	638729
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/02:23033137
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	apoptosis induction; caspase activation; Bax translocation (en)
http://linked.open.../riv/klicoveSlovo	apoptosis induction Bax translocation caspase activation
http://linked.open...ontrolniKodProRIV	[0D63A8D866BB]
http://linked.open...v/mistoKonaniAkce	Reims [FR]
http://linked.open...i/riv/mistoVydani	UK
http://linked.open...i/riv/nazevZdroje	Abstracts of the 25th Meeting of the European Study Group for Cell Proliferation (ESGCP).
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2002
http://linked.open...iv/tvurceVysledku	Koc, Michal Kovář, Jan Truksa, Jaroslav Ehrlichová, Marie Štýbrová, Hana
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2002-10-24 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
number of pages	2 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Blackwell Publishing

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