About: A novel lipid raft-associated glycoprotein, TEC-21, activates rat basophilic leukemia cells independently of the type 1 Fce receptor.

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About: A novel lipid raft-associated glycoprotein, TEC-21, activates rat basophilic leukemia cells independently of the type 1 Fce receptor. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We prepared monoclonal antibodies against lipid rafts from the rat basophilic leukemia cell line, RBL-2H3. One of the antibodies was found to recognize a novel glycosylphosphatidylinositol-anchored plasma membrane glycoprotein of 250 amino acids, designated TEC-21, containing a cysteine-rich domain homologous to those found in the urokinase plasminogen activator receptor/Ly6/snake neurotoxin family. The TEC-21 is abundant on the surface of RBL-2H3 cells (>106 molecules/cell) but is absent in numerous rat tissues except for testes. Aggregation of TEC-21 on RBL-2H3 cells induced a rapid increase in tyrosine phosphorylation of several substrates including Syk kinase and LAT adaptor, calcium flux, and release of secretory components. TEC-21-induced activation events were also observed in Fce receptorI-negative mutants of RBL-2H3 cells. The combined data suggest that TEC-21 is a novel lipid raft component of RBL-2H3 cells whose aggregation induces activation independently of Fce receptorI. We prepared monoclonal antibodies against lipid rafts from the rat basophilic leukemia cell line, RBL-2H3. One of the antibodies was found to recognize a novel glycosylphosphatidylinositol-anchored plasma membrane glycoprotein of 250 amino acids, designated TEC-21, containing a cysteine-rich domain homologous to those found in the urokinase plasminogen activator receptor/Ly6/snake neurotoxin family. The TEC-21 is abundant on the surface of RBL-2H3 cells (>106 molecules/cell) but is absent in numerous rat tissues except for testes. Aggregation of TEC-21 on RBL-2H3 cells induced a rapid increase in tyrosine phosphorylation of several substrates including Syk kinase and LAT adaptor, calcium flux, and release of secretory components. TEC-21-induced activation events were also observed in Fce receptorI-negative mutants of RBL-2H3 cells. The combined data suggest that TEC-21 is a novel lipid raft component of RBL-2H3 cells whose aggregation induces activation independently of Fce receptorI. (en)
Title	A novel lipid raft-associated glycoprotein, TEC-21, activates rat basophilic leukemia cells independently of the type 1 Fce receptor. A novel lipid raft-associated glycoprotein, TEC-21, activates rat basophilic leukemia cells independently of the type 1 Fce receptor. (en)
skos:prefLabel	A novel lipid raft-associated glycoprotein, TEC-21, activates rat basophilic leukemia cells independently of the type 1 Fce receptor. A novel lipid raft-associated glycoprotein, TEC-21, activates rat basophilic leukemia cells independently of the type 1 Fce receptor. (en)
skos:notation	RIV/68378050:_____/02:23033123!RIV/2004/GA0/A23004/N
http://linked.open.../vavai/riv/strany	213;223
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/00/0204), P(GA310/00/0205), P(GV312/96/K205), P(IAA5052005), P(IAA7052006), P(LN00A026), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Dráber, Petr Dráberová, Lubica Hálová, Ivana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	637134
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/02:23033123
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mast cell; plasma membrane; IgE (en)
http://linked.open.../riv/klicoveSlovo	plasma membrane IgE mast cell
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[97C5D0468765]
http://linked.open...i/riv/nazevZdroje	International Immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of Lyn kinase in membrane subdomains in antigen- and CD-48-mediated activation of mast cells Center of molecular and cellular immunology Regulatory role of TEC-21 membrane in mast cell activation Gene src and related src family protein tyrosine kinases (PTK) involvement in cell signalling and differentiation and their pathogenic and oncogenic activities The role of F-actin in mast cell activation Thy-1 membrane subdomains and Syk kinase in mast cell activation
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Dráber, Petr Dráberová, Lubica Hálová, Ivana
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	1460-2377
number of pages	11 (xsd:int)

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