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| Description
| - We report here the presence of numerous processed pseudogenes derived from the W family of endogenous retroviruses in the human genome. These pseudogenes are structurally colinear with the retroviral mRNA followed by a poly(A) tail. Our analysis of insertion sites of HERV-W processed pseudogenes shows a strong preference for the insertion motif of long interspersed nuclear element (LINE) retrotransposons. The genomic distribution, stability during evolution, and frequent truncations at the 5´ end resemble those of the pseudogenes generated by LINEs. We therefore suggest that HERV-W processed pseudogenes arose by multiple and independent LINE-mediated retrotransposition of retroviral mRNA. These data document that the majority of HERV-W copies are actually nontranscribed promoterless pseudogenes. The current search for HERV-Ws associated with several human diseases should concentrate on a small subset of transcriptionally competent elements
- We report here the presence of numerous processed pseudogenes derived from the W family of endogenous retroviruses in the human genome. These pseudogenes are structurally colinear with the retroviral mRNA followed by a poly(A) tail. Our analysis of insertion sites of HERV-W processed pseudogenes shows a strong preference for the insertion motif of long interspersed nuclear element (LINE) retrotransposons. The genomic distribution, stability during evolution, and frequent truncations at the 5´ end resemble those of the pseudogenes generated by LINEs. We therefore suggest that HERV-W processed pseudogenes arose by multiple and independent LINE-mediated retrotransposition of retroviral mRNA. These data document that the majority of HERV-W copies are actually nontranscribed promoterless pseudogenes. The current search for HERV-Ws associated with several human diseases should concentrate on a small subset of transcriptionally competent elements (en)
- Popisujeme zde přítomnost řady procesovaných pseudogenů odvozených z rodiny W endogenních retrovirů v lidském genomu. Tyto pseudogeny jsou strukturně kolineární, s retrovirovou mRNA ukončenou poly(A). Naše analýza inzerčních míst procesovaných pseudogenů HERV-W ukazuje silnou preferenci pro inzerční motiv retrotranspozonů LINE. Distribuce v genomu, stabilita během evoluce a časté zkracování na 5´-konci připomínají podobné jevy u pseudogenů generovaných LINE. Domníváme se proto, že procesované pseudogeny HERV-W vznikly mnohonásobnou a nezávislou retrotranspozicí retrovirové mRNA zprostředkovanou LINE. Tyto údaje ukazují, že většina kopií HERV-W ve skutečnosti představuje netranskribované pseudogeny bez promotorů. Současné hledání HERV-W spojených s různými lidskými chorobami by se mělo soustředit na malou podskupinu transkripčně kompetentních elementů (cs)
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| Title
| - Procesované pseudogeny lidských endogenních retrovirů generovaných LINE: jejich integrace, stabilita a distribuce (cs)
- Processed pseudogenes of human endogenous retroviruses generated by LINEs: their integration, stability, and distribution
- Processed pseudogenes of human endogenous retroviruses generated by LINEs: their integration, stability, and distribution (en)
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| skos:prefLabel
| - Procesované pseudogeny lidských endogenních retrovirů generovaných LINE: jejich integrace, stabilita a distribuce (cs)
- Processed pseudogenes of human endogenous retroviruses generated by LINEs: their integration, stability, and distribution
- Processed pseudogenes of human endogenous retroviruses generated by LINEs: their integration, stability, and distribution (en)
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| skos:notation
| - RIV/68378050:_____/02:00108987!RIV/2005/AV0/A23005/N
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA204/01/0632), P(LN00A079), Z(AV0Z5052915)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/02:00108987
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - pseudogenes; HERV; LINE (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Pačes, Jan
- Hejnar, Jiří
- Elleder, Daniel
- Pavlíček, Adam
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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