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  • Analýza funkce genů řídících expresi cytokinů ve zdraví a v nemoci. Srovnávali jsme produkci IL-4 a IL-10 v neinfekčních myších a v myších infikovaných Leishmania major a zjistili jsme, že gen Cypr3 (cytokine production 3) ovlivňuje expresi cytokinů v infikovaných i neinfikovaných myších, zatímco vliv Cypr1 je omezen na některé stavy (neinfikované myši). Cypr2 je umístěn společně s lokusem Lmr8 (Leishmania major response 8) na chromozomu 1, který řídí produkci IgE po infekci L. major. Tyto výsledky by mohly naznačovat, že existuje příčinná vazba mezi těmito dvěma lokusy nebo že obě tyto funkce jsou řízeny stejným genem (cs)
  • Analysis of function of genes that control the expression of cytokines in health and disease. We have compared production of IL-4 and IL-10 in uninfected mice and in mice infected by Leishmania major and we have found that gene Cypr3 (cytokine production 3) influences cytokine expression both in uninfected and infected mice, whereas the influence of Cypr1 is restricted to certain conditions (uninfected mice). Cypr2 colocalizes with locus Lmr8 (Leishmania major response 8) on chromosome 1 that controls IgE production after L. major infection. These results might indicate either causal link between these two loci or that both functions are controlled by the same gene
  • Analysis of function of genes that control the expression of cytokines in health and disease. We have compared production of IL-4 and IL-10 in uninfected mice and in mice infected by Leishmania major and we have found that gene Cypr3 (cytokine production 3) influences cytokine expression both in uninfected and infected mice, whereas the influence of Cypr1 is restricted to certain conditions (uninfected mice). Cypr2 colocalizes with locus Lmr8 (Leishmania major response 8) on chromosome 1 that controls IgE production after L. major infection. These results might indicate either causal link between these two loci or that both functions are controlled by the same gene (en)
Title
  • Genetic analysis of IgE expression
  • Genetic analysis of IgE expression (en)
  • Genetická analýza exprese IgE (cs)
skos:prefLabel
  • Genetic analysis of IgE expression
  • Genetic analysis of IgE expression (en)
  • Genetická analýza exprese IgE (cs)
skos:notation
  • RIV/68378050:_____/02:00105315!RIV/2005/AV0/A23005/N
http://linked.open.../vavai/riv/strany
  • 140
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GP310/02/P141), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika
  • Suppl.57
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 646932
http://linked.open...ai/riv/idVysledku
  • RIV/68378050:_____/02:00105315
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • gene; QTL; cytokine (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DK - Dánské království
http://linked.open...ontrolniKodProRIV
  • [13390876BAE0]
http://linked.open...i/riv/nazevZdroje
  • Allergy
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 57
http://linked.open...iv/tvurceVysledku
  • Král, V.
  • Havelková, Helena
  • Lipoldová, Marie
  • Blažková, Hana
  • Kosařová, Marcela
http://linked.open...n/vavai/riv/zamer
issn
  • 0105-4538
number of pages
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