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| rdf:type
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| Description
| - Měřením inkorporace bromodeoxyuridinu do replikující se DNA jsme zjistili, že imunosupresivní frakce kančí semenné plazmy (ISF) potlačuje proliferaci lymfocytů stimulovanou mitogeny: předběžné působení monoklonální protilátkou proti ISF či indomethacinem účinek ISF zvrátilo. Kromě toho jsme sledovali schopnost indomethacinu či monoklonální protilátky proti ISF zvrátit potlačení produkce protilátek vyvolané ISF měřením titru protilátek v krevním séru myší imunizovaných %22keyhole limpet%22 hemocyaninem pomocí ELISA. V nedávné době jsme popsali ISF jako komplex hlavních semenných glykoproteinů PSP I a PSP II. PSP II je složka odpovědná za imunosupresivní schopnosti tohoto komplexu. Abychom zjistili, zda je imunosupresivní účinek ISF spojen s jeho proteinovou či sacharidovou částí, zkoumali jsme u deglykosylovaného PSP II jeho antiproliferativní účinek na myší lymfocyty stimulované mitogeny. Výsledky ukazují, že deglykosylace PSP II neměla vliv na jeho antiproliferativní aktivitu. Z toho vyplývá, že imuno... (cs)
- By measuring bromodeoxyuridine incorporation into replicated DNA, we found that immunosuppressive fraction of boar seminal plasma (ISF) inhibited mitogen-stimulated lymphocyte proliferation; pretreatment with monoclonal antibody to ISF or indomethacin reversed the ISF effect. Besides, we followed the ability of indomethacin or monoclonal antibody to ISF to reverse ISF-induced suppression of antibody production by measuring antibody titers in the blood sera of mice immunized with keyhole limpet hemocyanin using ELISA. Recently we have identified ISF as a complex of the major seminal glycoproteins PSP I and PSP II. PSP II is the part that is responsible for immunosuppressive properties of the complex. To learn whether the ISF immunosuppressive effect is associated with its protein or saccharide part, we examined the deglycosylated PSP II for its antiproliferative effect on mitogen-stimulated mouse lymphocytes. The results suggest that deglycosylation of PSP II did not affect its antiproliferative ac...
- By measuring bromodeoxyuridine incorporation into replicated DNA, we found that immunosuppressive fraction of boar seminal plasma (ISF) inhibited mitogen-stimulated lymphocyte proliferation; pretreatment with monoclonal antibody to ISF or indomethacin reversed the ISF effect. Besides, we followed the ability of indomethacin or monoclonal antibody to ISF to reverse ISF-induced suppression of antibody production by measuring antibody titers in the blood sera of mice immunized with keyhole limpet hemocyanin using ELISA. Recently we have identified ISF as a complex of the major seminal glycoproteins PSP I and PSP II. PSP II is the part that is responsible for immunosuppressive properties of the complex. To learn whether the ISF immunosuppressive effect is associated with its protein or saccharide part, we examined the deglycosylated PSP II for its antiproliferative effect on mitogen-stimulated mouse lymphocytes. The results suggest that deglycosylation of PSP II did not affect its antiproliferative ac... (en)
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| Title
| - Reverse effect of indomethacin on the immunosuppressive activity of boar seminal immunosuppressive fraction
- Reverse effect of indomethacin on the immunosuppressive activity of boar seminal immunosuppressive fraction (en)
- Opačný efekt indomethacinu na imunosupresivní aktivitu kančí semenné imunosupresivní frakce (cs)
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| skos:prefLabel
| - Reverse effect of indomethacin on the immunosuppressive activity of boar seminal immunosuppressive fraction
- Reverse effect of indomethacin on the immunosuppressive activity of boar seminal immunosuppressive fraction (en)
- Opačný efekt indomethacinu na imunosupresivní aktivitu kančí semenné imunosupresivní frakce (cs)
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| skos:notation
| - RIV/68378050:_____/02:00105273!RIV/2005/AV0/A23005/N
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA303/01/0615), P(GV524/96/K162), P(KSK5011112), P(NI6883), Z(AV0Z5045916), Z(AV0Z5052915)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/02:00105273
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Indomethacin; Antibody response; Seminal immunosuppressive fraction (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Animal Reproduction Science
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Jonáková, Věra
- Pěknicová, Jana
- Železná, Blanka
- Holáň, Vladimír
- Zajícová, Alena
- Dostál, Jaromír
- Veselský, Leopold
- Kraus, Marek
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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