About: The leucine zipper region of Myb oncoprotein regulates commitment of hematopoietic progenitors.

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About: The leucine zipper region of Myb oncoprotein regulates commitment of hematopoietic progenitors. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The development of blood cells proceeds from pluripotent stem cells through multipotent progenitors into mature cells belonging to at least eight different leneages. We found that the leucine zipper region (LZR) of the v-Myb transcription factor affets the lineage commitment of myeloid progenitors. We propose that Myb LZR can function as a molecular switch affecting expression of lineage specifying factors and directing the development of hematopoietic progenitors into either myeloid or erythroid lineages. The development of blood cells proceeds from pluripotent stem cells through multipotent progenitors into mature cells belonging to at least eight different leneages. We found that the leucine zipper region (LZR) of the v-Myb transcription factor affets the lineage commitment of myeloid progenitors. We propose that Myb LZR can function as a molecular switch affecting expression of lineage specifying factors and directing the development of hematopoietic progenitors into either myeloid or erythroid lineages. (en)
Title	The leucine zipper region of Myb oncoprotein regulates commitment of hematopoietic progenitors. The leucine zipper region of Myb oncoprotein regulates commitment of hematopoietic progenitors. (en)
skos:prefLabel	The leucine zipper region of Myb oncoprotein regulates commitment of hematopoietic progenitors. The leucine zipper region of Myb oncoprotein regulates commitment of hematopoietic progenitors. (en)
skos:notation	RIV/68378050:_____/01:23010445!RIV/2003/AV0/A23003/N
http://linked.open.../vavai/riv/strany	3668;3676
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GV301/98/K042), P(IAA5052805), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	N/A
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Králová, Jarmila Čermák, Vladimír Dvořáková, Marta Dvořák, Michal Karafiát, Vít Bartůněk, Petr Pajer, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	685246
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/01:23010445
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hamatopoiesis; - commitment; - Myb (en)
http://linked.open.../riv/klicoveSlovo	- Myb - commitment hamatopoiesis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BC75E2A0B87C]
http://linked.open...i/riv/nazevZdroje	Blood
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Role of v-Myb oncoprotein in the cell cycle regulation of leukaemic monoblasts Acute monoblastic leukaemia: Analysis of molecular mechanisms and possibilities of targeted regulation
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	98
http://linked.open...iv/tvurceVysledku	Bartůněk, Petr Dvořák, Michal Králová, Jarmila Karafiát, Vít Čermák, Vladimír Pajer, Petr Dvořáková, Marta Zenke, M. Hořejší, Z.
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	0006-4971
number of pages	9 (xsd:int)

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