About: The N-terminal region and the mid-region complex of the integrin beta 2 subunit.

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About: The N-terminal region and the mid-region complex of the integrin beta 2 subunit. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The specificity of alpha(L)beta(2) pairing was found to be conferred by the I-like domain but not the NTR or mid-region. Epitopes of six anti-beta(2) mAbs were mapped using chimeric constructs. All except one (H52) require both the NTR and mid-region for epitope expression. Further results of this study suggest that the NTR/mid-region complex is involved in the regulation of LFA-1 function. The specificity of alpha(L)beta(2) pairing was found to be conferred by the I-like domain but not the NTR or mid-region. Epitopes of six anti-beta(2) mAbs were mapped using chimeric constructs. All except one (H52) require both the NTR and mid-region for epitope expression. Further results of this study suggest that the NTR/mid-region complex is involved in the regulation of LFA-1 function. (en)
Title	The N-terminal region and the mid-region complex of the integrin beta 2 subunit. The N-terminal region and the mid-region complex of the integrin beta 2 subunit. (en)
skos:prefLabel	The N-terminal region and the mid-region complex of the integrin beta 2 subunit. The N-terminal region and the mid-region complex of the integrin beta 2 subunit. (en)
skos:notation	RIV/68378050:_____/01:23010441!RIV/2003/AV0/A23003/N
http://linked.open.../vavai/riv/strany	36370;36376
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA310/99/0349), P(LN00A026), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	39
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Drbal, Karel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	689250
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/01:23010441
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	alpha(L)beta(2) integrin; - CD18; - lymphocytesfunction-associated antigen-1 (en)
http://linked.open.../riv/klicoveSlovo	- lymphocytesfunction-associated antigen-1 alpha(L)beta(2) integrin - CD18
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B726E45442B2]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of molecular and cellular immunology Low-affinity monoclonal antibodies as specific tolls targeting functionally important subsets of leukocyte surface receptors
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	276
http://linked.open...iv/tvurceVysledku	Drbal, Karel Shaw, J. M. Law, S. K. Robinson, M. K. Tan, S. M. van Kooyk, Y.
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	0021-9258
number of pages	7 (xsd:int)

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