About: Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton.

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About: Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Yeast 2-hybrid system was used to identify the abundant cytoplasmic adapter protein EBP50 as a specific binding partner of raft-associated transmembrane adapter PAG. The interaction involves the C-terminal sequence (TRL) of PAG and N-terminal PDZ domain(s) of EBP50. As EBP50 is known to interact via its C-terminal domain with the ERM-family proteins, which in turn bind to actin cytoskeleton, the PAG-EBP50 interaction may be important for connecting membrane rafts to the actin cytoskeleton. Yeast 2-hybrid system was used to identify the abundant cytoplasmic adapter protein EBP50 as a specific binding partner of raft-associated transmembrane adapter PAG. The interaction involves the C-terminal sequence (TRL) of PAG and N-terminal PDZ domain(s) of EBP50. As EBP50 is known to interact via its C-terminal domain with the ERM-family proteins, which in turn bind to actin cytoskeleton, the PAG-EBP50 interaction may be important for connecting membrane rafts to the actin cytoskeleton. (en)
Title	Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton. Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton. (en)
skos:prefLabel	Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton. Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton. (en)
skos:notation	RIV/68378050:_____/01:23010410!RIV/2003/AV0/A23003/N
http://linked.open.../vavai/riv/strany	133;136
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA7052904), P(LN00A026), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Brdička, Tomáš Hořejší, Václav Anděra, Ladislav Angelisová, Pavla Brdičková, Naděžda Špička, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	683209
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/01:23010410
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	PAG; - EBP50; - ezrin (en)
http://linked.open.../riv/klicoveSlovo	PAG - EBP50 - ezrin
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[51AC5AC36F87]
http://linked.open...i/riv/nazevZdroje	FEBS Letters
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of molecular and cellular immunology Signalling molecules of immunocytes: regulation of their activity by redox mechanisms and membrane compartmentalization
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	507
http://linked.open...iv/tvurceVysledku	Anděra, Ladislav Angelisová, Pavla Brdička, Tomáš Hořejší, Václav Špička, Jiří Brdičková, Naděžda Milgram, S. L.
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	0014-5793
number of pages	4 (xsd:int)

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