About: Overexpression of Pax5 is not sufficient for neoplastic transformation of mouse neuroectoderm.

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About: Overexpression of Pax5 is not sufficient for neoplastic transformation of mouse neuroectoderm. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Several Pax genes are involved in chromosomal translocations causing malignancies in humans, and Pax5 expression is deregulated in medulloblastomas. We have investigated whether Pax5 can induce tumors in the developing mouse brain. We then generated transgenic mice expressing human Pax5 under control of the Engrailed-2 promoter, which is expressed in the cerebellar external granule cell layer and in medulloblastomas. Several Pax genes are involved in chromosomal translocations causing malignancies in humans, and Pax5 expression is deregulated in medulloblastomas. We have investigated whether Pax5 can induce tumors in the developing mouse brain. We then generated transgenic mice expressing human Pax5 under control of the Engrailed-2 promoter, which is expressed in the cerebellar external granule cell layer and in medulloblastomas. (en)
Title	Overexpression of Pax5 is not sufficient for neoplastic transformation of mouse neuroectoderm. Overexpression of Pax5 is not sufficient for neoplastic transformation of mouse neuroectoderm. (en)
skos:prefLabel	Overexpression of Pax5 is not sufficient for neoplastic transformation of mouse neuroectoderm. Overexpression of Pax5 is not sufficient for neoplastic transformation of mouse neuroectoderm. (en)
skos:notation	RIV/68378050:_____/01:23010359!RIV/2003/AV0/A23003/N
http://linked.open.../vavai/riv/strany	459;467
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Kozmik, Zbyněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	690544
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/01:23010359
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Pax5; - retrovirus; - transgenic mice (en)
http://linked.open.../riv/klicoveSlovo	- retrovirus - transgenic mice Pax5
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[A05B56AF198B]
http://linked.open...i/riv/nazevZdroje	International Journal of Cancer
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	93
http://linked.open...iv/tvurceVysledku	Kozmik, Zbyněk Pfeffer, P. Steinbach, P. J. Aguzzi, A.
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	0020-7136
number of pages	9 (xsd:int)

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