About: Expression of BRCA1, NBR1 and NBR2 genes in human breast cancer cells.

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About: Expression of BRCA1, NBR1 and NBR2 genes in human breast cancer cells. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We estimated here the relative mRNA expression of BRCA1 NBR1 NBR2 genes on a panel of cell cultures derived from human breast cancer or normal mammary tissue, BRCA1 was significantly downregulated in 11 out of 12 examined tumor cell lines as compared to non-malignant mammary cells. The two isoforms of NBR1 were also found to be downregulated in malignant breast cells and the expression of NBR2 was increased in three permanent tumor cell lines and slightly decreased in all primary breast cancer cells. We estimated here the relative mRNA expression of BRCA1 NBR1 NBR2 genes on a panel of cell cultures derived from human breast cancer or normal mammary tissue, BRCA1 was significantly downregulated in 11 out of 12 examined tumor cell lines as compared to non-malignant mammary cells. The two isoforms of NBR1 were also found to be downregulated in malignant breast cells and the expression of NBR2 was increased in three permanent tumor cell lines and slightly decreased in all primary breast cancer cells. (en)
Title	Expression of BRCA1, NBR1 and NBR2 genes in human breast cancer cells. Expression of BRCA1, NBR1 and NBR2 genes in human breast cancer cells. (en)
skos:prefLabel	Expression of BRCA1, NBR1 and NBR2 genes in human breast cancer cells. Expression of BRCA1, NBR1 and NBR2 genes in human breast cancer cells. (en)
skos:notation	RIV/68378050:_____/01:23010296!RIV/2003/AV0/A23003/N
http://linked.open.../vavai/riv/strany	120;127
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/99/0354), P(GV204/98/K015), P(NC5614), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Dimitrov, Stoil Forejt, Jiří Matoušková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	680073
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/01:23010296
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	BRCA1; - NBR1; - NBR2 (en)
http://linked.open.../riv/klicoveSlovo	- NBR1 - NBR2 BRCA1
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[5963DBC405F4]
http://linked.open...i/riv/nazevZdroje	Folia Biologica (Praha)
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Cloning and analysis of genes involved in spermatogenic in carriers of chromosomal translocations and selfish t-haplotypes The use of cultured breast cancer cells for the development of the individualized chemosensitivity/chemoresistance assay in vitro. Molecular mapping of the mammalian genome and positional cloning of mammalian genes
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	47
http://linked.open...iv/tvurceVysledku	Forejt, Jiří Matoušková, Eva Dimitrov, Stoil
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	0015-5500
number of pages	8 (xsd:int)

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