About: Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer.

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About: Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We analyzed the experssion of carbonic anhydrase CA9 and CA12genes in a large sample of cancer cell lines, fresh and archival cell specimens, and normal human tissues. Expression of CA9 and CA12 in normal adult tissues was detected only in highly specialized cells and their expression did not overlap. In Von Hippel-Lindau (VHL)-defective tumors and/or under hypoxic conditions, CA9 and CA12 genes are overexpressed. We suggest that expression of CA9 and CA12 may be required for tumor progression. We analyzed the experssion of carbonic anhydrase CA9 and CA12genes in a large sample of cancer cell lines, fresh and archival cell specimens, and normal human tissues. Expression of CA9 and CA12 in normal adult tissues was detected only in highly specialized cells and their expression did not overlap. In Von Hippel-Lindau (VHL)-defective tumors and/or under hypoxic conditions, CA9 and CA12 genes are overexpressed. We suggest that expression of CA9 and CA12 may be required for tumor progression. (en)
Title	Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. (en)
skos:prefLabel	Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. (en)
skos:notation	RIV/68378050:_____/01:23010279!RIV/2003/AV0/A23003/N
http://linked.open.../vavai/riv/strany	905;919
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/99/0356), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Závada, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	680085
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/01:23010279
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	carbonic anhydrase 9; - hypoxia; - human cancer (en)
http://linked.open.../riv/klicoveSlovo	- human cancer - hypoxia carbonic anhydrase 9
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[F76A70E74A0A]
http://linked.open...i/riv/nazevZdroje	American Journal of Pathology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	MN protein: Role of binding to cell surface molecules in oncogenesis
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	158
http://linked.open...iv/tvurceVysledku	Ivanova, A. Stanbridge, E. J. Ivanov, S. Lee, J. Závada, Jan Danilkovitch-Miagkova, A. Lerman, M. I. Merrill, M. J. Oldfield, E. H. Proescholdt, M. A. Shu-Yuan, L. Sly, W. Tarasova, N. Waheed, A. Weirich, G.
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	0002-9440
number of pages	15 (xsd:int)

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