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rdf:type
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Description
| - Here we show that removal of cellular cholesterol bycyclodextrin suppressed the activation through lipid raftcomponent, Thy-1, as determined by tyrosine phosphorylation of Syk kinase and modulation of cytoplasmic calcium. In contrast, the FceRI-mediated activation events were more resistant. Cyclodextrin treatment increased secretory response in both Thy-1- and FceRI-activated cells. Thus, cholesterol depletion does not merely block receptor signaling but has more complex consequences.
- Here we show that removal of cellular cholesterol bycyclodextrin suppressed the activation through lipid raftcomponent, Thy-1, as determined by tyrosine phosphorylation of Syk kinase and modulation of cytoplasmic calcium. In contrast, the FceRI-mediated activation events were more resistant. Cyclodextrin treatment increased secretory response in both Thy-1- and FceRI-activated cells. Thus, cholesterol depletion does not merely block receptor signaling but has more complex consequences. (en)
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Title
| - Differential sensitivity to acute cholesterol lowering of activation mediated via the high-affinity IgE receptor and Thy-1 glycoprotein.
- Differential sensitivity to acute cholesterol lowering of activation mediated via the high-affinity IgE receptor and Thy-1 glycoprotein. (en)
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skos:prefLabel
| - Differential sensitivity to acute cholesterol lowering of activation mediated via the high-affinity IgE receptor and Thy-1 glycoprotein.
- Differential sensitivity to acute cholesterol lowering of activation mediated via the high-affinity IgE receptor and Thy-1 glycoprotein. (en)
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skos:notation
| - RIV/68378050:_____/01:23010263!RIV/2003/AV0/A23003/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA204/00/0204), P(GA310/00/0205), P(GV312/96/K205), P(IAA5052005), P(IAA7052006), P(LN00A026), P(NM18), Z(AV0Z5052915)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/01:23010263
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - lipid rafts; - cyclodextrin; - cholesterol (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - European Journal of Immunology
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...ocetUcastnikuAkce
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http://linked.open...nichUcastnikuAkce
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Dráber, Petr
- Dráberová, Lubica
- Boubelík, Michael
- Kovářová, Martina
- Surviladze, Zurab
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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