About: Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants

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About: Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The cells were treated for 24 h with B[a]P (1 μM, 10 μM, 25 μM) and EOMs (1 μg/ml, 10 μg/ml, 25 μg/ml). 25 μM of B[a]P and most of the tested doses of EOMs induced double strand breaks (DSBs) as indicated by H2AX phosphorylation. DNA damage was accompanied by induction of XRCC4 expression and an increased frequency of chromosomal aberrations. Translocations most frequently affected chromosome 7. We observed only a weak induction of Ku70/80 expression as well as ligation activity of nuclear extracts. The cells were treated for 24 h with B[a]P (1 μM, 10 μM, 25 μM) and EOMs (1 μg/ml, 10 μg/ml, 25 μg/ml). 25 μM of B[a]P and most of the tested doses of EOMs induced double strand breaks (DSBs) as indicated by H2AX phosphorylation. DNA damage was accompanied by induction of XRCC4 expression and an increased frequency of chromosomal aberrations. Translocations most frequently affected chromosome 7. We observed only a weak induction of Ku70/80 expression as well as ligation activity of nuclear extracts. (en)
Title	Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants (en)
skos:prefLabel	Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants (en)
skos:notation	RIV/68378041:_____/14:00435644!RIV15-GA0-68378041
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP503/11/0084)
http://linked.open...iv/cisloPeriodika	MAY-JUN 2014
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Šrám, Radim Rössnerová, Andrea Topinka, Jan Rössner ml., Pavel Uhlířová, Kateřina Líbalová, Helena Beskid, Olena Tabashidze, Nana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	32758
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/14:00435644
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	benzo[a]pyrene; chromosome aberrations; double-strand DNA breaks (en)
http://linked.open.../riv/klicoveSlovo	benzo[a]pyrene chromosome aberrations double-strand DNA breaks
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[8002F4CE3E82]
http://linked.open...i/riv/nazevZdroje	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	The effect of polycyclic aromatic hydrocarbons and particulate matter on DNA damage and DNA repair mechanisms in vitro
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	763-764
http://linked.open...iv/tvurceVysledku	Beskid, Olena Rössnerová, Andrea Rössner ml., Pavel Topinka, Jan Uhlířová, Kateřina Šrám, Radim Líbalová, Helena Tabashidze, Nana
http://linked.open...ain/vavai/riv/wos	000336694800004
issn	0027-5107
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.mrfmmm.2014.03.006

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