About: A Low-Molecular Weight Dialyzable Leukocyte Extract Selectively Enhances the Development of CD4+RORt+ T Cells and IL-17 Production

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About: A Low-Molecular Weight Dialyzable Leukocyte Extract Selectively Enhances the Development of CD4+RORt+ T Cells and IL-17 Production Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A low-molecular weight dialyzable leukocyte extract (called transfer factor) has been used for many years in clinic to improve or modulate immune response. However, the mechanism of its action remained obscure. Here we showed that transfer factor modulates the production of various cytokines by activated T cells and that the most profound immunoregulatory effect of transfer factort can be seen on the development of Th17 cells and interleukin-17 productiion. Transfer factor significantly enhanced the production of proinflammatory cytokine IL-17. A low-molecular weight dialyzable leukocyte extract (called transfer factor) has been used for many years in clinic to improve or modulate immune response. However, the mechanism of its action remained obscure. Here we showed that transfer factor modulates the production of various cytokines by activated T cells and that the most profound immunoregulatory effect of transfer factort can be seen on the development of Th17 cells and interleukin-17 productiion. Transfer factor significantly enhanced the production of proinflammatory cytokine IL-17. (en)
Title	A Low-Molecular Weight Dialyzable Leukocyte Extract Selectively Enhances the Development of CD4+RORt+ T Cells and IL-17 Production A Low-Molecular Weight Dialyzable Leukocyte Extract Selectively Enhances the Development of CD4+RORt+ T Cells and IL-17 Production (en)
skos:prefLabel	A Low-Molecular Weight Dialyzable Leukocyte Extract Selectively Enhances the Development of CD4+RORt+ T Cells and IL-17 Production A Low-Molecular Weight Dialyzable Leukocyte Extract Selectively Enhances the Development of CD4+RORt+ T Cells and IL-17 Production (en)
skos:notation	RIV/68378041:_____/14:00435536!RIV15-AV0-68378041
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(LO1309)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Holáň, Vladimír Zajícová, Alena Krulová, Magdalena Svobodová, Eliška Chudíčková, Milada Trošan, Peter
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	803
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/14:00435536
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	enzyme-linked immunosorbent assay; interferon; interleukin (en)
http://linked.open.../riv/klicoveSlovo	enzyme-linked immunosorbent assay interleukin interferon
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[188AC57C0902]
http://linked.open...i/riv/nazevZdroje	Folia Biologica
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Buněčná terapie a tkáňové náhrady
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	60
http://linked.open...iv/tvurceVysledku	Holáň, Vladimír Trošan, Peter Zajícová, Alena Krulová, Magdaléna Javorková, Eliška Chudičková, Milada
http://linked.open...ain/vavai/riv/wos	000347748000001
issn	0015-5500
number of pages	8 (xsd:int)

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