About: Down-regulation of adipogenesis of mesenchymal stem cells by oscillating high-gradient magnetic fields and mechanical vibration

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About: Down-regulation of adipogenesis of mesenchymal stem cells by oscillating high-gradient magnetic fields and mechanical vibration Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Here, we show that oscillating high-gradient magnetic field (HGMF) and mechanical vibration affect adipogenic differentiation of mesenchymal stem cells by the transmission of mechanical stress to the cell cytoskeleton, resulting in F-actin remodelling and subsequent down-regulation of adipogenic genes adiponectin, PPARγ, and AP2. Our findings propose an insight into the regulation of cellular nanomechanics, and provide a basis for better controlled down-regulation of stem cell adipogenesis by HGMF, which may facilitate the development of challenging therapeutic strategies suitable for the remote control of biological systems. Here, we show that oscillating high-gradient magnetic field (HGMF) and mechanical vibration affect adipogenic differentiation of mesenchymal stem cells by the transmission of mechanical stress to the cell cytoskeleton, resulting in F-actin remodelling and subsequent down-regulation of adipogenic genes adiponectin, PPARγ, and AP2. Our findings propose an insight into the regulation of cellular nanomechanics, and provide a basis for better controlled down-regulation of stem cell adipogenesis by HGMF, which may facilitate the development of challenging therapeutic strategies suitable for the remote control of biological systems. (en)
Title	Down-regulation of adipogenesis of mesenchymal stem cells by oscillating high-gradient magnetic fields and mechanical vibration Down-regulation of adipogenesis of mesenchymal stem cells by oscillating high-gradient magnetic fields and mechanical vibration (en)
skos:prefLabel	Down-regulation of adipogenesis of mesenchymal stem cells by oscillating high-gradient magnetic fields and mechanical vibration Down-regulation of adipogenesis of mesenchymal stem cells by oscillating high-gradient magnetic fields and mechanical vibration (en)
skos:notation	RIV/68378041:_____/14:00433524!RIV15-GA0-68378041
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP304/11/0653), P(GAP304/12/1370), P(LO1309)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Syková, Eva Holáň, Vladimír Trošan, Peter Novotná, Božena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	12322
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/14:00433524
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	stem cells; cytoskeleton; magnetic field; cell growth (en)
http://linked.open.../riv/klicoveSlovo	stem cells cell growth magnetic field cytoskeleton
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[57B3F4E944F9]
http://linked.open...i/riv/nazevZdroje	Applied Physics Letters
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Targeted differentiation and transdifferentiation of limbal and mesenchymal stem cells and their therapeutic applications in preclinical models Superparamagnetic iron-oxide nanoparticles for cellular imaging and their effect on genotoxicity, cytotocixity and stem cell differentiation. Buněčná terapie a tkáňové náhrady
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	105
http://linked.open...iv/tvurceVysledku	Dejneka, Alexandr Syková, Eva Holáň, Vladimír Kubinová, Šárka Trošan, Peter Zablotskyy, Vitaliy A. Churpita, Olexandr Novotná, Božena Lunov, Oleg
http://linked.open...ain/vavai/riv/wos	000342758700077
issn	0003-6951
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1063/1.4895459

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