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rdf:type
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Description
| - We performed a multistage genome-wide association study including 7683 individuals with pancreatic cancer and 14397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74–0.84, P = 3.0 1012), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30–1.65, P = 1.1 1010), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10–1.20, P = 2.4 109) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12–1.25, P = 1.2 108). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76–0.85, P = 9.8 1014). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 107) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.
- We performed a multistage genome-wide association study including 7683 individuals with pancreatic cancer and 14397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74–0.84, P = 3.0 1012), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30–1.65, P = 1.1 1010), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10–1.20, P = 2.4 109) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12–1.25, P = 1.2 108). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76–0.85, P = 9.8 1014). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 107) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies. (en)
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Title
| - Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
- Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer (en)
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skos:prefLabel
| - Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
- Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer (en)
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skos:notation
| - RIV/68378041:_____/14:00431859!RIV15-AV0-68378041
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378041:_____/14:00431859
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - disease; variants; genetic susceptibility (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Campa, D.
- Canzian, F.
- Kraft, P.
- …
- White, E.
- Jenab, M.
- Kaaks, R.
- Gallinger, S.
- Kogevinas, M.
- Li, D.
- Innocenti, F.
- Bugert, P.
- Büchler, M. W.
- Capurso, G.
- Key, T. J.
- Khaw, K. T.
- Rizzato, C.
- Zheng, W.
- Funel, N.
- Costello, E.
- Andreotti, G.
- Hassan, M.
- Bracci, P. M.
- Cotterchio, M.
- Duell, E. J.
- Holly, E. A.
- Olson, S. H.
- Petersen, G. M.
- Gross, M.
- Abnet, Ch. C.
- Albanes, D.
- Arslan, A. A.
- Austin, M. A.
- Barfield, R.
- Basso, D.
- Beane-Freeman, L.
- Berndt, S. I.
- Boutron-Ruault, M. Ch.
- Brotzman, M.
- Bueno-de-Mesquita, H. B.
- Burdette, L.
- Buring, J.
- Caporaso, N. E.
- Chung, Ch.
- Elena, J.
- Gaziano, J. M.
- Giese, N. A.
- Giles, G. G.
- Giovannucci, E. L.
- Goggins, M.
- Goodman, G. E.
- Goodman, P. J.
- Gorman, M. J.
- Haiman, Ch. A.
- Helzlsouer, K. J.
- Henderson, B. E.
- Hu, N.
- Hunter, D. J.
- Jacobs, E. J.
- Kamineni, A.
- Klein, A. P.
- Klein, E. A.
- Kolonel, L. N.
- Kooperberg, Ch.
- Kulke, M. H.
- Malats, N.
- Risch, H. A.
- Sesso, H. D.
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