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  • We performed a multistage genome-wide association study including 7683 individuals with pancreatic cancer and 14397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74–0.84, P = 3.0 1012), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30–1.65, P = 1.1 1010), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10–1.20, P = 2.4 109) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12–1.25, P = 1.2 108). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76–0.85, P = 9.8 1014). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 107) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.
  • We performed a multistage genome-wide association study including 7683 individuals with pancreatic cancer and 14397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74–0.84, P = 3.0 1012), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30–1.65, P = 1.1 1010), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10–1.20, P = 2.4 109) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12–1.25, P = 1.2 108). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76–0.85, P = 9.8 1014). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 107) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies. (en)
Title
  • Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
  • Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer (en)
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  • Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
  • Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer (en)
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  • RIV/68378041:_____/14:00431859!RIV15-AV0-68378041
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  • disease; variants; genetic susceptibility (en)
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  • Campa, D.
  • Canzian, F.
  • Kraft, P.
  • …
  • White, E.
  • Jenab, M.
  • Kaaks, R.
  • Gallinger, S.
  • Kogevinas, M.
  • Li, D.
  • Innocenti, F.
  • Bugert, P.
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  • Khaw, K. T.
  • Rizzato, C.
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  • Costello, E.
  • Andreotti, G.
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  • Olson, S. H.
  • Petersen, G. M.
  • Gross, M.
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  • Chung, Ch.
  • Elena, J.
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  • Goodman, G. E.
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  • Helzlsouer, K. J.
  • Henderson, B. E.
  • Hu, N.
  • Hunter, D. J.
  • Jacobs, E. J.
  • Kamineni, A.
  • Klein, A. P.
  • Klein, E. A.
  • Kolonel, L. N.
  • Kooperberg, Ch.
  • Kulke, M. H.
  • Malats, N.
  • Risch, H. A.
  • Sesso, H. D.
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