About: Polymorphisms in DNA repair genes, recreational physical activity and breast cancer risk

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Polymorphisms in MMR (mismatch repair) or other DNA repair gene variants may modify the association between recreational physical activity (RPA) and breast cancer incidence. In this study, the individual and joint effects of variants in three MMR pathway genes (MSH3, MLH1 and MSH2) on breast cancer occurence using resources from the Long Island Breast Cancer Study Project were investigated. Additionally, the interactions between RPA and genetic polymorphisms in MMR, BER (base excision repair) and NER (nucleotide excision repair) pathways were characterized. Obtained data show that women with minor alleles in both MSH2 and MLH1 could be at increased breast cancer risk. RPA may be modified by genes in the DNA repair pathway, and merit further investigation. Polymorphisms in MMR (mismatch repair) or other DNA repair gene variants may modify the association between recreational physical activity (RPA) and breast cancer incidence. In this study, the individual and joint effects of variants in three MMR pathway genes (MSH3, MLH1 and MSH2) on breast cancer occurence using resources from the Long Island Breast Cancer Study Project were investigated. Additionally, the interactions between RPA and genetic polymorphisms in MMR, BER (base excision repair) and NER (nucleotide excision repair) pathways were characterized. Obtained data show that women with minor alleles in both MSH2 and MLH1 could be at increased breast cancer risk. RPA may be modified by genes in the DNA repair pathway, and merit further investigation. (en)
Title	Polymorphisms in DNA repair genes, recreational physical activity and breast cancer risk Polymorphisms in DNA repair genes, recreational physical activity and breast cancer risk (en)
skos:prefLabel	Polymorphisms in DNA repair genes, recreational physical activity and breast cancer risk Polymorphisms in DNA repair genes, recreational physical activity and breast cancer risk (en)
skos:notation	RIV/68378041:_____/14:00395393!RIV15-AV0-68378041
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Rössner ml., Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	37437
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/14:00395393
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	breast cacner; epidemiology; DNA repair (en)
http://linked.open.../riv/klicoveSlovo	epidemiology DNA repair breast cacner
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[554BF9EFD92B]
http://linked.open...i/riv/nazevZdroje	International Journal of Cancer
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	134
http://linked.open...iv/tvurceVysledku	Rössner ml., Pavel Olshan, A. F. Santella, R. M. Eng, S. M. Neugut, A. I. Teitelbaum, S. L. Terry, M. B. Bradshaw, P. T. Cleveland, R. J. Crew, C. D. Grammon, M. D. McCullough, L. E. Millikan, R. C. North, K. E. Shen, J.
http://linked.open...ain/vavai/riv/wos	000326880600016
issn	0020-7136
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/ijc.28383

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