About: The effect of parvalbumin deficiency on the acoustic startle response and prepulse inhibition in mice

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The strength of the acoustic startle response (ASR) to short bursts of broadband noise or tone pips (4, 8 and 16 kHz) and the prepulse inhibition (PPI) of the ASR elicited by prepulse tones (4, 8 and 16 kHz) were measured in parvalbumin-deficient (PV-/-) mice and in age-matched PV+/+ mice as controls. In PV-/- mice, we observed smaller ASR amplitudes in response to relatively weak startling stimuli (80-90 dB SPL) of either broadband noise or 8-kHz tones compared to those recorded in PV+/+ mice. For these startling stimuli, PV-/- mice had higher ASR thresholds and longer ASR latencies. PPI of the ASR in PV-/- mice was less effective than in PV+/+ mice, for all tested prepulse frequencies (4, 8 or 16 kHz) at 70 dB SPL. Our findings demonstrate no effect of PV deficiency on hearing threshold as determined from recordings of auditory brainstem responses in PV -/- mice. However, the frequency-specific differences in the ASR and the significant reduction of PPI of ASR reflect specific changes in neuronal circuits, mainly inhibitory, in the auditory centers in PV-deficient mice. The strength of the acoustic startle response (ASR) to short bursts of broadband noise or tone pips (4, 8 and 16 kHz) and the prepulse inhibition (PPI) of the ASR elicited by prepulse tones (4, 8 and 16 kHz) were measured in parvalbumin-deficient (PV-/-) mice and in age-matched PV+/+ mice as controls. In PV-/- mice, we observed smaller ASR amplitudes in response to relatively weak startling stimuli (80-90 dB SPL) of either broadband noise or 8-kHz tones compared to those recorded in PV+/+ mice. For these startling stimuli, PV-/- mice had higher ASR thresholds and longer ASR latencies. PPI of the ASR in PV-/- mice was less effective than in PV+/+ mice, for all tested prepulse frequencies (4, 8 or 16 kHz) at 70 dB SPL. Our findings demonstrate no effect of PV deficiency on hearing threshold as determined from recordings of auditory brainstem responses in PV -/- mice. However, the frequency-specific differences in the ASR and the significant reduction of PPI of ASR reflect specific changes in neuronal circuits, mainly inhibitory, in the auditory centers in PV-deficient mice. (en)
Title	The effect of parvalbumin deficiency on the acoustic startle response and prepulse inhibition in mice The effect of parvalbumin deficiency on the acoustic startle response and prepulse inhibition in mice (en)
skos:prefLabel	The effect of parvalbumin deficiency on the acoustic startle response and prepulse inhibition in mice The effect of parvalbumin deficiency on the acoustic startle response and prepulse inhibition in mice (en)
skos:notation	RIV/68378041:_____/13:00396572!RIV14-MSM-68378041
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(EE2.3.30.0018), P(GAP304/12/1342)
http://linked.open...iv/cisloPeriodika	October
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Popelář, Jiří Syka, Josef Rybalko, Natalia Burianová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	71658
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/13:00396572
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	parvalbumin-deficient mice; acoustic startle reflex; prepulse inhibition (en)
http://linked.open.../riv/klicoveSlovo	acoustic startle reflex parvalbumin-deficient mice prepulse inhibition
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[9C38303A53E5]
http://linked.open...i/riv/nazevZdroje	Neuroscience Letters
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of Research Teams of IEM AS CR for the BIOCEV Project Pathological changes in the central auditory system accompanying aging
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	553
http://linked.open...iv/tvurceVysledku	Popelář, Jiří Rybalko, Natalia Syka, Josef Burianová, Jana Schwaller, B.
http://linked.open...ain/vavai/riv/wos	000326008700041
issn	0304-3940
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.neulet.2013.08.042

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