About: Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments

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About: Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Gene expression levels are significantly regulated by DNA methylation. In this study the methylation profiles in children (7-15 years) with and without asthma from two regions with different levels of air pollution (a highly polluted Ostrava region and a control Prachatice region) were studied. Results demonstrate a significant impact of different environmental conditions on the DNA methylation patterns of children from the two regions. No difference in DNA methylation patterns was found between children with and without bronchial asthma in individual locations, but patterns in both asthmatic and healthy children differed between Ostrava and Prachatice. Further, differences in DNA methylation pattern depending on gender and urinary cotinine levels were observed. Other factors including lenght of gestation, birth weight and lenght of full breastfeeding are suggested as possible factors that can impact the DNA methylation pattern in future life. Gene expression levels are significantly regulated by DNA methylation. In this study the methylation profiles in children (7-15 years) with and without asthma from two regions with different levels of air pollution (a highly polluted Ostrava region and a control Prachatice region) were studied. Results demonstrate a significant impact of different environmental conditions on the DNA methylation patterns of children from the two regions. No difference in DNA methylation patterns was found between children with and without bronchial asthma in individual locations, but patterns in both asthmatic and healthy children differed between Ostrava and Prachatice. Further, differences in DNA methylation pattern depending on gender and urinary cotinine levels were observed. Other factors including lenght of gestation, birth weight and lenght of full breastfeeding are suggested as possible factors that can impact the DNA methylation pattern in future life. (en)
Title	Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments (en)
skos:prefLabel	Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments (en)
skos:notation	RIV/68378041:_____/13:00395370!RIV14-GA0-68378041
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GA13-13458S), P(GAP503/11/0084)
http://linked.open...iv/cisloPeriodika	January
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Šrám, Radim Rössnerová, Andrea Rössner ml., Pavel Schmuczerová, Jana Dostál, Miroslav Tulupova, Elena Tabashidze, Nana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	74538
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/13:00395370
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	27K BeadChip; air pollution; bronchial asthma (en)
http://linked.open.../riv/klicoveSlovo	27K BeadChip air pollution bronchial asthma
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[9BA00CECA557]
http://linked.open...i/riv/nazevZdroje	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Impact of air pollution to genome of newborns The effect of polycyclic aromatic hydrocarbons and particulate matter on DNA damage and DNA repair mechanisms in vitro
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	741-742
http://linked.open...iv/tvurceVysledku	Rössnerová, Andrea Rössner ml., Pavel Schmuczerová, Jana Šrám, Radim Dostál, Miroslav Tabashidze, Nana Gmuender, H. Tulupová, Elena
http://linked.open...ain/vavai/riv/wos	000318456400003
issn	0027-5107
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.mrfmmm.2013.02.003

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