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  • Many colorectal cancers (CRCs) develop in genetically susceptible individuals most of whom are not carriers of germ line mismatch repair or APC gene mutations and much of the heritable risk of CRC appears to be attributable to the co-inheritance of multiple low-risk variants. The accumulated experience to date in identifying this class of susceptibility allele has highlighted the need to conduct statistically and methodologically rigorous studies and the need for the multi-centre collaboration. This has been the motivation for establishing the COGENT(COlorectal cancer GENeTics) consortium which now includes over 20 research groups in Europe, Australia, the Americas, China and Japan actively working on CRC genetics. Here, we review the rationale for identifying lowpenetrance variants for CRC and the current and future challenges for COGENT.
  • Many colorectal cancers (CRCs) develop in genetically susceptible individuals most of whom are not carriers of germ line mismatch repair or APC gene mutations and much of the heritable risk of CRC appears to be attributable to the co-inheritance of multiple low-risk variants. The accumulated experience to date in identifying this class of susceptibility allele has highlighted the need to conduct statistically and methodologically rigorous studies and the need for the multi-centre collaboration. This has been the motivation for establishing the COGENT(COlorectal cancer GENeTics) consortium which now includes over 20 research groups in Europe, Australia, the Americas, China and Japan actively working on CRC genetics. Here, we review the rationale for identifying lowpenetrance variants for CRC and the current and future challenges for COGENT. (en)
Title
  • COGENT (COlorectal cancer GENeTics) revisited
  • COGENT (COlorectal cancer GENeTics) revisited (en)
skos:prefLabel
  • COGENT (COlorectal cancer GENeTics) revisited
  • COGENT (COlorectal cancer GENeTics) revisited (en)
skos:notation
  • RIV/68378041:_____/12:00383027!RIV13-AV0-68378041
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 127597
http://linked.open...ai/riv/idVysledku
  • RIV/68378041:_____/12:00383027
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • identification of low-risk variants; disease causing variants; susceptibility alleles (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [AFB93C3CF626]
http://linked.open...i/riv/nazevZdroje
  • Mutagenesis
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 27
http://linked.open...iv/tvurceVysledku
  • Hemminki, K.
  • Naccarati, Alessio
  • Vodička, Pavel
  • Souček, P.
  • Matsuda, K.
  • Moreno, V.
  • Li, L.
  • Brenner, H.
  • Buch, S.
  • Hampe, J.
  • Schafmayer, C.
  • Völzke, H.
  • von Schönfels, W.
  • Aaltonen, L. A.
  • Campbell, H.
  • Carracedo, A.
  • Carvajal-Carmona, L.
  • Castells, A.
  • Castellví-Bel, S.
  • Cheadle, J. P.
  • Devilee, P.
  • Dunlop, M.
  • Echeverry, M.
  • Gallinger, S.
  • Galvan, A.
  • Ho, J. W. C.
  • Hofstra, R. M. W.
  • Hudson, T. J.
  • Kirac, I.
  • Lerch, M. M.
  • Lindblom, A.
  • Lipton, L.
  • Maughan, T. S.
  • Morreau, H.
  • Nakamura, Y.
  • Peterlongo, P.
  • Pharoah, P. D.
  • Radice, P.
  • Ruiz-Ponte, C.
  • Schmidt, C. A.
  • Schreiber, S.
  • Scott, R.
  • Sham, P.
  • Sieber, O.
  • Tenesa, A.
  • Tomplinson, P. M.
  • Velez, A.
  • Villanueva, C. M.
  • Wijnen, J. T.
  • Zanke, B.
  • van Wezel, T.
http://linked.open...ain/vavai/riv/wos
  • 000300040200002
http://linked.open...n/vavai/riv/zamer
issn
  • 0267-8357
number of pages
http://bibframe.org/vocab/doi
  • 10.1093/mutage/ger059
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