About: Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of this study was to evaluate the targeting of mesenchymal stem cells labeled with superparamagnetic iron oxide nanoparticles to the site of a spinal cord injury by means of a magnetic implant. We monitored both the distribution and the number of cells in the lesion site after their intrathecal administration and the effect of the magnetic implant on cell transplantation. The cell distribution correlated with the calculated distribution of magnetic forces exerted on the transplanted cells in the subarachnoid space and the lesion site. Our results showed that the targeting efficiency can be increased by using magnets that produce spatially modulated stray fields. We suggested a mathematical model of cell targeting kinetics and analyzed those parameters of the magnetic system critical for efficient cell targeting. The aim of this study was to evaluate the targeting of mesenchymal stem cells labeled with superparamagnetic iron oxide nanoparticles to the site of a spinal cord injury by means of a magnetic implant. We monitored both the distribution and the number of cells in the lesion site after their intrathecal administration and the effect of the magnetic implant on cell transplantation. The cell distribution correlated with the calculated distribution of magnetic forces exerted on the transplanted cells in the subarachnoid space and the lesion site. Our results showed that the targeting efficiency can be increased by using magnets that produce spatially modulated stray fields. We suggested a mathematical model of cell targeting kinetics and analyzed those parameters of the magnetic system critical for efficient cell targeting. (en)
Title	Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury (en)
skos:prefLabel	Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury (en)
skos:notation	RIV/68378041:_____/12:00383008!RIV13-AV0-68378041
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(GAP304/11/0189), P(GAP304/11/0653), P(GAP304/11/0731), P(GAP304/12/1370), P(IAA500390902), V, Z(AV0Z10100522), Z(AV0Z40500505), Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika	16 Jul
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Syková, Eva Kubinová, Šárka Růžička, Jiří Jendelová, Pavla Vaněček, Václav Forostyak, Serhiy
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	139009
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/12:00383008
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nanoparticles; mesenchymal stem cells; magnetic targeting (en)
http://linked.open.../riv/klicoveSlovo	nanoparticles magnetic targeting mesenchymal stem cells
http://linked.open...odStatuVydavatele	NZ - Nový Zéland
http://linked.open...ontrolniKodProRIV	[24E49F893A52]
http://linked.open...i/riv/nazevZdroje	International Journal of Nanomedicine
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	The use of stem cells and biomaterials for spinal cord injury repair Targeted differentiation and transdifferentiation of limbal and mesenchymal stem cells and their therapeutic applications in preclinical models Superparamagnetic iron-oxide nanoparticles for cellular imaging and their effect on genotoxicity, cytotocixity and stem cell differentiation. The use of stem cells in the treatment of amyotrophic lateral sclerosis Spinal cord injury repair using biomodified hydrogels with oriented channels
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Dejneka, Alexandr Růžička, Jiří Syková, Eva Kubinová, Šárka Herynek, V. Jendelová, Pavla Zablotskyy, Vitaliy A. Vaněček, Václav Forostyak, Serhiy Babič, Michal
http://linked.open...ain/vavai/riv/wos	000306404400001
http://linked.open...n/vavai/riv/zamer	Wave and Corpuscular Light Propagation, Optical Materials and Technology Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie New biotechnologies, nanomaterials and stem cells for use in regenerative medicine
issn	1178-2013
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.2147/IJN.S32824

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