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| rdf:type
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| Description
| - Regulation of and coordination between DNA repair genes is fundamental for maintaining genome stability, and post-transcriptional gene regulation by microRNAs is of particular relevance. In this context, the presence of single nucleotide polymorphisms (SNPs) within the 3´-untranslated regions of target DNA repair genes could alter the binding with specific miRNAs,modulating gene expression and affecting cancer susceptibility. In this study, we investigated the role of genetic variations in miRNA-binding sites of nucleotide excision repair (NER) genes in association with colorectal cancer (CRC) risk. We tested those SNPs based on 28 NER genes in 1098 colorectal cancer cases and 1469 healthy controls from the Czech Republic. Rs7356 in RPA2 and rs4596 in GTF2H1 were associated with colorectal cancer risk. After stratification for tumor location, the association of both SNPs was significant only for rectal cancer (rs7356: OR 1.52, 95% CI 1.02–2.26, P = 0.04 and rs4596: OR 0.69, 95% CI 0.50–0.94, P = 0.02; results not adjusted for multiple testing). Variation in miRNA target binding sites in the 3´-untranslated region of NER genes may be important for modulating CRC risk, with a different relevance according to tumor location.
- Regulation of and coordination between DNA repair genes is fundamental for maintaining genome stability, and post-transcriptional gene regulation by microRNAs is of particular relevance. In this context, the presence of single nucleotide polymorphisms (SNPs) within the 3´-untranslated regions of target DNA repair genes could alter the binding with specific miRNAs,modulating gene expression and affecting cancer susceptibility. In this study, we investigated the role of genetic variations in miRNA-binding sites of nucleotide excision repair (NER) genes in association with colorectal cancer (CRC) risk. We tested those SNPs based on 28 NER genes in 1098 colorectal cancer cases and 1469 healthy controls from the Czech Republic. Rs7356 in RPA2 and rs4596 in GTF2H1 were associated with colorectal cancer risk. After stratification for tumor location, the association of both SNPs was significant only for rectal cancer (rs7356: OR 1.52, 95% CI 1.02–2.26, P = 0.04 and rs4596: OR 0.69, 95% CI 0.50–0.94, P = 0.02; results not adjusted for multiple testing). Variation in miRNA target binding sites in the 3´-untranslated region of NER genes may be important for modulating CRC risk, with a different relevance according to tumor location. (en)
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| Title
| - Polymorphisms in miRNA binding sites of nucleotide excision repair genes and colorectal cancer risk
- Polymorphisms in miRNA binding sites of nucleotide excision repair genes and colorectal cancer risk (en)
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| skos:prefLabel
| - Polymorphisms in miRNA binding sites of nucleotide excision repair genes and colorectal cancer risk
- Polymorphisms in miRNA binding sites of nucleotide excision repair genes and colorectal cancer risk (en)
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| skos:notation
| - RIV/68378041:_____/12:00379749!RIV13-AV0-68378041
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| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - I, P(GAP304/10/1286), P(GP305/09/P194), Z(AV0Z50390703)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68378041:_____/12:00379749
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - DNA repair; polymorphisms; miRNA binding sites (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Naccarati, Alessio
- Novotný, J.
- Pardini, Barbara
- Vodička, Pavel
- Slyšková, Jana
- Poláková, Veronika
- Levý, M.
- Landi, D.
- Landi, S.
- Lipská, L.
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://bibframe.org/vocab/doi
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