About: Polydendrocytes Display Large Lineage Plasticity following Focal Cerebral Ischemia

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Here we show that polydendrocytes participate in CNS repair following focal cerebral ischemia. We followed their fate after a permanent middle cerebral artery occlusion (MCAo) in adult NG2creBAC:ZEG double transgenic mice, in which enhanced green fluorescent protein (EGFP) is expressed in polydendrocytes and their progeny. We found that 3 days after MCAo the EGFP(+) cells markedly proliferate,. however, in later phases after MCAo they give rise to a subpopulation of reactive astrocytes and moreover, some EGFP(+) cells expressed doublecortin and displayed membrane properties typical for neural precursor cells, Taken together, our data indicate that polydendrocytes in the dorsal cortex display multipotent differentiation potential after focal ischemia. Here we show that polydendrocytes participate in CNS repair following focal cerebral ischemia. We followed their fate after a permanent middle cerebral artery occlusion (MCAo) in adult NG2creBAC:ZEG double transgenic mice, in which enhanced green fluorescent protein (EGFP) is expressed in polydendrocytes and their progeny. We found that 3 days after MCAo the EGFP(+) cells markedly proliferate,. however, in later phases after MCAo they give rise to a subpopulation of reactive astrocytes and moreover, some EGFP(+) cells expressed doublecortin and displayed membrane properties typical for neural precursor cells, Taken together, our data indicate that polydendrocytes in the dorsal cortex display multipotent differentiation potential after focal ischemia. (en)
Title	Polydendrocytes Display Large Lineage Plasticity following Focal Cerebral Ischemia Polydendrocytes Display Large Lineage Plasticity following Focal Cerebral Ischemia (en)
skos:prefLabel	Polydendrocytes Display Large Lineage Plasticity following Focal Cerebral Ischemia Polydendrocytes Display Large Lineage Plasticity following Focal Cerebral Ischemia (en)
skos:notation	RIV/68378041:_____/12:00379159!RIV13-AV0-68378041
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GA305/09/0717), P(GAP303/12/0855), P(GD309/08/H079), Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Pivoňková, Helena Anděrová, Miroslava Honsa, Pavel Filipová, Marcela Džamba, Dávid
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	159539
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/12:00379159
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NG2 glia; CNS regeneration; patch clamp (en)
http://linked.open.../riv/klicoveSlovo	patch clamp CNS regeneration NG2 glia
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BB828FC963BB]
http://linked.open...i/riv/nazevZdroje	PLoS ONE
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	PhD program in neuroscience Polydendrocyte function in regeneration after ischemic brain injury - the role of Wnt signaling pathway Induction of neuro- and gliogenesis in rat brain after ischemia - the role of morphogenes and growth factors in the nervous tissue regeneration.
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Pivoňková, Helena Anděrová, Miroslava Džamba, Dávid Honsa, Pavel Filipová, Marcela
http://linked.open...ain/vavai/riv/wos	000305336400038
http://linked.open...n/vavai/riv/zamer	New biotechnologies, nanomaterials and stem cells for use in regenerative medicine
issn	1932-6203
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pone.0036816

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