About: Phosphonate-Titanium Dioxide Assemblies: Platform for Multimodal Diagnostic-Therapeutic Nanoprobes

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Phosphonate-Titanium Dioxide Assemblies: Platform for Multimodal Diagnostic-Therapeutic Nanoprobes Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Multimodal imaging-therapeutic nanoprobe TiO2@RhdGd was prepared and successfully used for in vitro and in vivo cell tracking as well as for killing of cancer cells in vitro. TiO2 nanoparticles were used as a core for phosphonic acid modified functionalities, responsible for contrast in MRI and optical imaging. The probe shows high 1H relaxivity and relaxivity density values. Presence of fluorescent dye allows for visualization by means of fluorescence microscopy. The applicability of the probe was studied, using mesenchymal stem cells, cancer HeLa cells, and T-lymphocytes. The probe did not exhibit toxicity in any of these systems. Labeled cells were successfully visualized in vitro by means of fluorescence microscopy and MRI. Furthermore, it was shown that the probe TiO2@RhdGd can be changed into a cancer cell killer upon UV light irradiation. The above stated results represent a valuable proof of a principle showing applicability of the probe design for diagnosis and therapy. Multimodal imaging-therapeutic nanoprobe TiO2@RhdGd was prepared and successfully used for in vitro and in vivo cell tracking as well as for killing of cancer cells in vitro. TiO2 nanoparticles were used as a core for phosphonic acid modified functionalities, responsible for contrast in MRI and optical imaging. The probe shows high 1H relaxivity and relaxivity density values. Presence of fluorescent dye allows for visualization by means of fluorescence microscopy. The applicability of the probe was studied, using mesenchymal stem cells, cancer HeLa cells, and T-lymphocytes. The probe did not exhibit toxicity in any of these systems. Labeled cells were successfully visualized in vitro by means of fluorescence microscopy and MRI. Furthermore, it was shown that the probe TiO2@RhdGd can be changed into a cancer cell killer upon UV light irradiation. The above stated results represent a valuable proof of a principle showing applicability of the probe design for diagnosis and therapy. (en)
Title	Phosphonate-Titanium Dioxide Assemblies: Platform for Multimodal Diagnostic-Therapeutic Nanoprobes Phosphonate-Titanium Dioxide Assemblies: Platform for Multimodal Diagnostic-Therapeutic Nanoprobes (en)
skos:prefLabel	Phosphonate-Titanium Dioxide Assemblies: Platform for Multimodal Diagnostic-Therapeutic Nanoprobes Phosphonate-Titanium Dioxide Assemblies: Platform for Multimodal Diagnostic-Therapeutic Nanoprobes (en)
skos:notation	RIV/68378041:_____/11:00368636!RIV12-AV0-68378041
http://linked.open...avai/riv/aktivita	P S V Z
http://linked.open...avai/riv/aktivity	P(OC 179), S, V, Z(AV0Z50390703), Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	14
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Jendelová, Pavla Kapcalová, Miroslava
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	220208
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/11:00368636
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MRI contrast agent; stem-cell therapy; Ti02 particles (en)
http://linked.open.../riv/klicoveSlovo	MRI contrast agent Ti02 particles stem-cell therapy
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[97E9054F67C7]
http://linked.open...i/riv/nazevZdroje	Journal of Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	CA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20179
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	54
http://linked.open...iv/tvurceVysledku	Kotek, J. Herynek, V. Jendelová, Pavla Jirák, D. Lukeš, I. Černý, J. Kapcalová, Miroslava Hermann, P. Kubíček, V. Vilímová, V. Řehoř, I.
http://linked.open...ain/vavai/riv/wos	000292892300021
http://linked.open...n/vavai/riv/zamer	New biotechnologies, nanomaterials and stem cells for use in regenerative medicine Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	0022-2623
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/jm200449y

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software