About: Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Several studies have shown that susceptibility to complex diseases can be mediated by ancestral alleles. Using RNAi screening, CTNNBL1 was identified as a putative regulator of the Wnt signaling pathway, which plays a key role in colorectal carcinogenesis. We investigated whether genetic variation in CTNNBL1 affects susceptibility to CRC and tested for signals of recent selection. In the Czech cohort, containing sporadic cases, the ancestral alleles of three SNPs showed evidence of association with CRC: rs2344481 (OR 1.44, 95%CI 1.06-1.95, dominant model), rs2281148 (OR 0.59, 95%CI 0.36-0.96, dominant model) and rs2235460 (OR 1.38, 95%CI 1.01-1.89, AA vs. GG). The associations were less prominent in the family/early onset-based German cohort. Data derived from several databases and statistical tests Several studies have shown that susceptibility to complex diseases can be mediated by ancestral alleles. Using RNAi screening, CTNNBL1 was identified as a putative regulator of the Wnt signaling pathway, which plays a key role in colorectal carcinogenesis. We investigated whether genetic variation in CTNNBL1 affects susceptibility to CRC and tested for signals of recent selection. In the Czech cohort, containing sporadic cases, the ancestral alleles of three SNPs showed evidence of association with CRC: rs2344481 (OR 1.44, 95%CI 1.06-1.95, dominant model), rs2281148 (OR 0.59, 95%CI 0.36-0.96, dominant model) and rs2235460 (OR 1.38, 95%CI 1.01-1.89, AA vs. GG). The associations were less prominent in the family/early onset-based German cohort. Data derived from several databases and statistical tests (en)
Title	Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications (en)
skos:prefLabel	Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications (en)
skos:notation	RIV/68378041:_____/11:00367867!RIV12-AV0-68378041
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vodičková, Ludmila Vodička, Pavel Naccarati, Alessio Pardini, Barbara
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	221256
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/11:00367867
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	colorectal cancer; case-control study; selective pressure (en)
http://linked.open.../riv/klicoveSlovo	colorectal cancer case-control study selective pressure
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[256A2AA1FA8F]
http://linked.open...i/riv/nazevZdroje	International Journal of Molecular Epidemiology and Genetics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	29 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	2
http://linked.open...iv/tvurceVysledku	Büttner, R. Försti, A. Görgens, H. Hemminki, K. Holinski-Feder, E. Kloor, M. Loeffler, M. Morak, M. Naccarati, Alessio Novotný, J. Pardini, Barbara Propping, P. Rahner, N. Schackert, H. K. Steinke, V. Vodička, Pavel Vodičková, Ludmila Bermejo, J. L. Bevier, M. Boutros, M. Cruciat, C. M. Demir, K. Goecke, T. Huber, W. Huhn, S. Ingelfinger, D. Niehrs, C. Pox, C. P. Renneberg, R.
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	1948-1756
number of pages	15 (xsd:int)

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