About: MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic

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About: MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Polymorphic variants in genes involved in metabolisms of dietary folate may modulate the risk for colorectal cancer through aberrant DNA-methylation and altered nucleotide synthesis and repair. In the present study, we have assessed the association of six polymorphisms and relative haplotypes in the MTHFR and MTRR genes with the risk for colorectal cancer in the Czech Republic. We have concluded that the 677TT genotype and the TA haplotype in the MTHFR gene may also play a role in colorectal cancer risk in the Czech population. No difference in the distribution between cases and controls was observed for the haplotypes based on the four polymorphisms in the MTRR gene. Polymorphic variants in genes involved in metabolisms of dietary folate may modulate the risk for colorectal cancer through aberrant DNA-methylation and altered nucleotide synthesis and repair. In the present study, we have assessed the association of six polymorphisms and relative haplotypes in the MTHFR and MTRR genes with the risk for colorectal cancer in the Czech Republic. We have concluded that the 677TT genotype and the TA haplotype in the MTHFR gene may also play a role in colorectal cancer risk in the Czech population. No difference in the distribution between cases and controls was observed for the haplotypes based on the four polymorphisms in the MTRR gene. (en)
Title	MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic (en)
skos:prefLabel	MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic (en)
skos:notation	RIV/68378041:_____/11:00367822!RIV12-MZ0-68378041
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GAP304/10/1286), P(GP305/09/P194), P(NS10230), Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vodičková, Ludmila Vodička, Pavel Poláková, Veronika Naccarati, Alessio Pardini, Barbara
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	214154
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/11:00367822
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Colorectal cancer risk; MTHFR; MTRR (en)
http://linked.open.../riv/klicoveSlovo	Colorectal cancer risk MTHFR MTRR
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[FDD419D97EDD]
http://linked.open...i/riv/nazevZdroje	Mutation Research - Genetic Toxicology and Environmental Mutagenesis
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Polymorphisms in the MTHFR gene: susceptibility to colorectal cancer and role in the response to therapy DNA repair and sporadic colorectal cancer. Rationalization of strategy of oncological treatment of radically inoperable colorectal liver metastases
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	721
http://linked.open...iv/tvurceVysledku	Försti, A. Hemminki, K. Naccarati, Alessio Novotný, J. Pardini, Barbara Vodička, Pavel Vodičková, Ludmila Poláková, Veronika Kumar, R. Prasad, R. B.
http://linked.open...ain/vavai/riv/wos	000288843300006
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	1383-5718
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.mrgentox.2010.12.008

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