About: 5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes

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About: 5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Treatment with 5-fluorouracil is known to improve survival in various cancers, mainly in colorectal cancer. Crucial metabolite of 5 FU depends on methylene-tetrahydro-folate reductase, MTHFR. We investigated 6 genetic variants in the MTHFR and MTRR genes on the clinical outcome of 273 patients treated by 5FU. One variant in MTHFR gene showed association with progression-free survival in heterozygotes and homozygotes bearers and is connected with statistically significant better survival. None of other investigated variants showed any association with the survival. Treatment with 5-fluorouracil is known to improve survival in various cancers, mainly in colorectal cancer. Crucial metabolite of 5 FU depends on methylene-tetrahydro-folate reductase, MTHFR. We investigated 6 genetic variants in the MTHFR and MTRR genes on the clinical outcome of 273 patients treated by 5FU. One variant in MTHFR gene showed association with progression-free survival in heterozygotes and homozygotes bearers and is connected with statistically significant better survival. None of other investigated variants showed any association with the survival. (en)
Title	5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes 5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes (en)
skos:prefLabel	5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes 5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes (en)
skos:notation	RIV/68378041:_____/11:00367817!RIV12-AV0-68378041
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(GAP304/10/1286), P(GP305/09/P194), V, Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vodička, Pavel Naccarati, Alessio Pardini, Barbara
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	244207
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/11:00367817
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	fluorouracil; DNA-damage; nepolymorphisms (en)
http://linked.open.../riv/klicoveSlovo	fluorouracil DNA-damage nepolymorphisms
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[DEB4547EB584]
http://linked.open...i/riv/nazevZdroje	British Journal of Clinical Pharmacology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Polymorphisms in the MTHFR gene: susceptibility to colorectal cancer and role in the response to therapy DNA repair and sporadic colorectal cancer.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	72
http://linked.open...iv/tvurceVysledku	Försti, A. Hemminki, K. Naccarati, Alessio Pardini, Barbara Vodička, Pavel Kumar, R. Prasad, R. B. Bermejo, J. L.
http://linked.open...ain/vavai/riv/wos	000292505500019
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	0306-5251
number of pages	2 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1365-2125.2010.03892.x

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