About: Expression of XRCC5 in peripheral blood lymphocytes is upregulated in subjects from a heavily polluted region in the Czech Republic

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About: Expression of XRCC5 in peripheral blood lymphocytes is upregulated in subjects from a heavily polluted region in the Czech Republic Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The levels of oxidative stress markers [8-oxodG, 15-F2t-IsoP, protein carbonyls] and cytogenetic parameters [FG/100, %AB.C., and (ace)] in subjects living in Prague (N=64) and in the heavily polluted Ostrava region (N=75) were investigated. Despite the fact, that the levels of air pollutants were significantly higher in Ostrava vs. Prague, neither differences in biomarkers of oxidative stress or in cytogenetic parameters between these two locations were found. Subjects living in Ostrava has increased odds of having above-median levels of XRCC5 expression. Above-median levels of 8-oxodG were associated with decreased levels of vitamin C and E, which were elevated in subjects from Ostrava. It may be concluded, that air pollution by c-PAHs affects XRCC5 gene expression, which probably protects subjects from Ostrava against the induction of a higher frequency of translocations, and elevated vitamin C and E levels decrease the levels of 8-oxodG. The levels of oxidative stress markers [8-oxodG, 15-F2t-IsoP, protein carbonyls] and cytogenetic parameters [FG/100, %AB.C., and (ace)] in subjects living in Prague (N=64) and in the heavily polluted Ostrava region (N=75) were investigated. Despite the fact, that the levels of air pollutants were significantly higher in Ostrava vs. Prague, neither differences in biomarkers of oxidative stress or in cytogenetic parameters between these two locations were found. Subjects living in Ostrava has increased odds of having above-median levels of XRCC5 expression. Above-median levels of 8-oxodG were associated with decreased levels of vitamin C and E, which were elevated in subjects from Ostrava. It may be concluded, that air pollution by c-PAHs affects XRCC5 gene expression, which probably protects subjects from Ostrava against the induction of a higher frequency of translocations, and elevated vitamin C and E levels decrease the levels of 8-oxodG. (en)
Title	Expression of XRCC5 in peripheral blood lymphocytes is upregulated in subjects from a heavily polluted region in the Czech Republic Expression of XRCC5 in peripheral blood lymphocytes is upregulated in subjects from a heavily polluted region in the Czech Republic (en)
skos:prefLabel	Expression of XRCC5 in peripheral blood lymphocytes is upregulated in subjects from a heavily polluted region in the Czech Republic Expression of XRCC5 in peripheral blood lymphocytes is upregulated in subjects from a heavily polluted region in the Czech Republic (en)
skos:notation	RIV/68378041:_____/11:00365854!RIV12-MZP-68378041
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B08005), P(SP/1B3/8/08), Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Šrám, Radim Rössnerová, Andrea Rössner ml., Pavel Švecová, Vlasta Uhlířová, Kateřina Beskid, Olena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	199034
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/11:00365854
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	oxidative stress; chromosomal aberrations; gene expression (en)
http://linked.open.../riv/klicoveSlovo	gene expression chromosomal aberrations oxidative stress
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[5C2D689E37E8]
http://linked.open...i/riv/nazevZdroje	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	The impact of air pollution to human health in the Ostrava region using genomic methods - AIRGEN New approaches to study the toxicity of the air pollution and their contribution to assess limits for selected pollutants.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	713
http://linked.open...iv/tvurceVysledku	Beskid, Olena Rössnerová, Andrea Rössner ml., Pavel Uhlířová, Kateřina Šrám, Radim Švecová, Vlasta
http://linked.open...ain/vavai/riv/wos	000293930400009
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	0027-5107
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.mrfmmm.2011.06.001

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