About: Shh Expression in a Rudimentary Tooth Offers New Insights Into Development of the Mouse Incisor

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Shh Expression in a Rudimentary Tooth Offers New Insights Into Development of the Mouse Incisor Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Using a combination of histology, 3D reconstructions and Shh whole mount in situ hybridization (WISH) analyses, several Sonic hedgehog (Shh) expression domains have been shown sequentially appearing in the lower WT mouse incisor region during early development. In contrast to the single Shh expression domain that is widely assumed to be present in each lower incisor area at ED12.5-13.5, two spatially distinct regions of Shh expression have been identified that appeared in an anterior-posterior sequence during this period. The initial anterior, more superficially located Shh expression region represented the rudimentary (so-called deciduous) incisor, whereas only the later posterior deeper situated region corresponded to the prospective functional incisor. These findings strongly suggest the necessity to re-interpret previous results based on either morphology alone or on the detection of signaling molecules alone, and offer a new insight into the interpretation of existing data from mutant mice. Using a combination of histology, 3D reconstructions and Shh whole mount in situ hybridization (WISH) analyses, several Sonic hedgehog (Shh) expression domains have been shown sequentially appearing in the lower WT mouse incisor region during early development. In contrast to the single Shh expression domain that is widely assumed to be present in each lower incisor area at ED12.5-13.5, two spatially distinct regions of Shh expression have been identified that appeared in an anterior-posterior sequence during this period. The initial anterior, more superficially located Shh expression region represented the rudimentary (so-called deciduous) incisor, whereas only the later posterior deeper situated region corresponded to the prospective functional incisor. These findings strongly suggest the necessity to re-interpret previous results based on either morphology alone or on the detection of signaling molecules alone, and offer a new insight into the interpretation of existing data from mutant mice. (en)
Title	Shh Expression in a Rudimentary Tooth Offers New Insights Into Development of the Mouse Incisor Shh Expression in a Rudimentary Tooth Offers New Insights Into Development of the Mouse Incisor (en)
skos:prefLabel	Shh Expression in a Rudimentary Tooth Offers New Insights Into Development of the Mouse Incisor Shh Expression in a Rudimentary Tooth Offers New Insights Into Development of the Mouse Incisor (en)
skos:notation	RIV/68378041:_____/11:00364584!RIV12-AV0-68378041
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(GA304/07/0223), P(GA304/09/1579), S, Z(AV0Z50390512), Z(AV0Z50520514), Z(MSM0021620843)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Peterková, Renata Churavá, Svatava Hovořáková, Mária Smrčková, Lucie Peterka, Miroslav Procházka, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	229118
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/11:00364584
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	morphogenesis; human embryos; deciduous dentition (en)
http://linked.open.../riv/klicoveSlovo	morphogenesis deciduous dentition human embryos
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[0F2B07CF14D9]
http://linked.open...i/riv/nazevZdroje	Journal of Experimental Zoology Part B: Molecular and Developmental Evolution Additional Title Information
http://linked.open...in/vavai/riv/obor	EA
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Developmental anomalies of dentition in phylogenetic context Development of incisor malfomations in mouse model
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	346B
http://linked.open...iv/tvurceVysledku	Kozmik, Zbyněk Peterková, Renata Procházka, Jan Churavá, Svatava Hovořáková, Mária Lesot, H. Boráň, T. Klein, O. Peterka, Miroslav Smrčková, Lucie
http://linked.open...ain/vavai/riv/wos	000291699400005
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů ANTROPOLOGIE KOMUNIKACE A LIDSKÉ ADAPTACE
issn	1552-5007
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/jez.b.21408

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software