About: Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling

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About: Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In Sprouty loss of function mutants, splitting of gene expression domains and reduced apoptosis was associated with subdivision of the incisor primordium and a multiplication of its stem cell-containing regions. The changes in Sprouty gene dosage led to a graded change in incisor number, with progressive decreases in Sprouty dosage leading to increasing numbers of teeth. The independent development of two incisors in mutants with large decreases in Sprouty dosage mimicked the likely condition of rodent ancestors. Our findings indicate that altering genetic dosage of an antagonist can recapitulate ancestral dental characters, and that tooth number can be progressively regulated by changing levels of activity of a single signal transduction pathway. In Sprouty loss of function mutants, splitting of gene expression domains and reduced apoptosis was associated with subdivision of the incisor primordium and a multiplication of its stem cell-containing regions. The changes in Sprouty gene dosage led to a graded change in incisor number, with progressive decreases in Sprouty dosage leading to increasing numbers of teeth. The independent development of two incisors in mutants with large decreases in Sprouty dosage mimicked the likely condition of rodent ancestors. Our findings indicate that altering genetic dosage of an antagonist can recapitulate ancestral dental characters, and that tooth number can be progressively regulated by changing levels of activity of a single signal transduction pathway. (en)
Title	Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling (en)
skos:prefLabel	Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling (en)
skos:notation	RIV/68378041:_____/11:00364583!RIV12-AV0-68378041
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA304/07/0223), P(GA304/09/1579), S, Z(AV0Z50390512), Z(MSM0021620843)
http://linked.open...iv/cisloPeriodika	18
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Peterková, Renata Churavá, Svatava Hovořáková, Mária
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	226280
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/11:00364583
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	FGF signaling; Sprouty genes; Incisor (en)
http://linked.open.../riv/klicoveSlovo	FGF signaling Incisor Sprouty genes
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[CFF08D519841]
http://linked.open...i/riv/nazevZdroje	Development
http://linked.open...in/vavai/riv/obor	EA
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	14 (xsd:int)
http://linked.open...vavai/riv/projekt	Developmental anomalies of dentition in phylogenetic context Development of incisor malfomations in mouse model
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	138
http://linked.open...iv/tvurceVysledku	Peterková, Renata Ahn, Y. Balooch, G. Biehs, B. Charles, C. Churavá, Svatava Hovořáková, Mária Jheon, A. Klein, O. D. Krumlauf, R. Lesot, H. Lyons, D. B. Marangoni, P. Viriot, L.
http://linked.open...ain/vavai/riv/wos	000294156000021
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie ANTROPOLOGIE KOMUNIKACE A LIDSKÉ ADAPTACE
issn	0950-1991
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1242/dev.069195

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