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  • The effect of exposure to carcinogenic PAHs adsorbed onto respirable air particles on DNA adducts and chromosomal aberrations was repeatedly studied in groups of policemen and bus drivers from Prague, Czech Republic. Personal exposure was evaluated using personal samplers during working shifts. DNA adducts were analyzed in lymphocytes by the 32P-postlabeling assay and chromosomal aberrations by conventional cytogenetic analysis and by fluorescent in situ hybridization (FISH). The studies suggest that the environmental exposure of nonsmokers to concentrations higher than 1 ng B[a]P/m3 represents a risk to DNA damage, as indicated by an increase in DNA adducts and in the genomic frequency of translocations determined by FISH.
  • The effect of exposure to carcinogenic PAHs adsorbed onto respirable air particles on DNA adducts and chromosomal aberrations was repeatedly studied in groups of policemen and bus drivers from Prague, Czech Republic. Personal exposure was evaluated using personal samplers during working shifts. DNA adducts were analyzed in lymphocytes by the 32P-postlabeling assay and chromosomal aberrations by conventional cytogenetic analysis and by fluorescent in situ hybridization (FISH). The studies suggest that the environmental exposure of nonsmokers to concentrations higher than 1 ng B[a]P/m3 represents a risk to DNA damage, as indicated by an increase in DNA adducts and in the genomic frequency of translocations determined by FISH. (en)
Title
  • Biomarkers of exposure and effect – interpretation for human risk
  • Biomarkers of exposure and effect – interpretation for human risk (en)
skos:prefLabel
  • Biomarkers of exposure and effect – interpretation for human risk
  • Biomarkers of exposure and effect – interpretation for human risk (en)
skos:notation
  • RIV/68378041:_____/11:00363581!RIV12-MZP-68378041
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(SL/5/160/05), P(SP/1B3/8/08), Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 188366
http://linked.open...ai/riv/idVysledku
  • RIV/68378041:_____/11:00363581
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • personal monitoring; benzo[a]pyrene; carcinogenic polycyclic aromatic hydrocarbons (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [593ED2B1019A]
http://linked.open...i/riv/nazevZdroje
  • Air Quality, Atmosphere and Health (AQAH)
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 4
http://linked.open...iv/tvurceVysledku
  • Beskid, Olena
  • Binková, Blanka
  • Milcová, Alena
  • Rössnerová, Andrea
  • Rössner ml., Pavel
  • Rössner, P.
  • Solanský, I.
  • Topinka, Jan
  • Šrám, Radim
http://linked.open...n/vavai/riv/zamer
issn
  • 1873-9318
number of pages
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