About: Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer´s disease

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About: Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer´s disease Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Our results show for the first time that the increase in the density of resting microglia precedes both plaque formation and activation of microglia by extracellular Aβ accumulation. We suggest that AD pathology triggers a complex microglial reaction: at the initial stages of the disease the number of resting microglia increases, as if in preparation for the ensuing activation in an attempt to fight the extracellular Aβ load that is characteristic of the terminal stages of the disease. Our results show for the first time that the increase in the density of resting microglia precedes both plaque formation and activation of microglia by extracellular Aβ accumulation. We suggest that AD pathology triggers a complex microglial reaction: at the initial stages of the disease the number of resting microglia increases, as if in preparation for the ensuing activation in an attempt to fight the extracellular Aβ load that is characteristic of the terminal stages of the disease. (en)
Title	Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer´s disease Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer´s disease (en)
skos:prefLabel	Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer´s disease Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer´s disease (en)
skos:notation	RIV/68378041:_____/10:00357625!RIV11-GA0-68378041
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/08/1384), P(GA309/09/1696), Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Rodriguez Arellano, Jose Julio Verkhratsky, Alexei
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	263363
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/10:00357625
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microglia; Alzheimer´s disease; hippocampus (en)
http://linked.open.../riv/klicoveSlovo	hippocampus Alzheimer´s disease microglia
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[7C5E9FAEB498]
http://linked.open...i/riv/nazevZdroje	Cell Death & Disease
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Age-related changes in the structure and function of astrocytes Pathological potential of astroglia in Alzheimer disease
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	1
http://linked.open...iv/tvurceVysledku	Noristani, H. N. Olabarria, M. Rodriguez Arellano, Jose Julio Verkhratsky, Alexei Witton, J.
http://linked.open...ain/vavai/riv/wos	000279616300001
http://linked.open...n/vavai/riv/zamer	New biotechnologies, nanomaterials and stem cells for use in regenerative medicine
issn	2041-4889
number of pages	6 (xsd:int)

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