About: Associations between Polycyclic Aromatic Hydrocarbon-Related Exposures and p53 Mutations in Breast Tumors

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About: Associations between Polycyclic Aromatic Hydrocarbon-Related Exposures and p53 Mutations in Breast Tumors Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The study tested the hypothesis that associations of PAH-related exposures with breast cancer differ according to tumor p53 mutation status, effect, type, and number. This possibility was examined in a population-based case-control study where p53 mutations in 859 tumors were detected. Participants with p53 mutations were less likely to be exposed to polycyclic aromatic hydrocarbons (PAHs) than participants without mutations. In conclusion, the study suggests that PAHs may be associated with specific breast tumor p53 mutation subgroup rather than with overall p53 mutations and may be related to breast cancer through mechanisms other than p53 mutation. The study tested the hypothesis that associations of PAH-related exposures with breast cancer differ according to tumor p53 mutation status, effect, type, and number. This possibility was examined in a population-based case-control study where p53 mutations in 859 tumors were detected. Participants with p53 mutations were less likely to be exposed to polycyclic aromatic hydrocarbons (PAHs) than participants without mutations. In conclusion, the study suggests that PAHs may be associated with specific breast tumor p53 mutation subgroup rather than with overall p53 mutations and may be related to breast cancer through mechanisms other than p53 mutation. (en)
Title	Associations between Polycyclic Aromatic Hydrocarbon-Related Exposures and p53 Mutations in Breast Tumors Associations between Polycyclic Aromatic Hydrocarbon-Related Exposures and p53 Mutations in Breast Tumors (en)
skos:prefLabel	Associations between Polycyclic Aromatic Hydrocarbon-Related Exposures and p53 Mutations in Breast Tumors Associations between Polycyclic Aromatic Hydrocarbon-Related Exposures and p53 Mutations in Breast Tumors (en)
skos:notation	RIV/68378041:_____/10:00347653!RIV11-AV0-68378041
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Rössner ml., Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	247972
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/10:00347653
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	breast cancer; p53 mutation; p53 overexpression (en)
http://linked.open.../riv/klicoveSlovo	p53 overexpression p53 mutation breast cancer
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6EE2641F82D7]
http://linked.open...i/riv/nazevZdroje	Environmental Health Perspectives
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	19 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	118
http://linked.open...iv/tvurceVysledku	Rössner ml., Pavel Agrawal, M. Conway-Dorsey, K. Eng, S. M. Gammon, M. D. Garbowski, G. Gaudet, M. M. Hibshoosh, H. Long, CH.M. Mansukhani, M. Memeo, L. Mordukhovich, I. Neugut, A. I. Sagiv, S. K. Santella, R. Steck, S. E. Teitelbaum, S. L. Terry, M. B. Zhang, Y. J.
http://linked.open...ain/vavai/riv/wos	000276454800024
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	0091-6765
number of pages	8 (xsd:int)

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