About: Mutagenesis Is Elevated in Male Germ Cells Obtained from DNA Polymerase-beta Heterozygous Mice     Goto   Sponge   NotDistinct   Permalink

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  • The spontaneous mutant frequency for mixed spermatogenic cells prepared from Pol heterozygous mice was significantly greater than that of wild-type controls, but no significant effect was found among the somatic tissues tested. Results shown in the paper demonstrate that normal Pol abundance is necessary for normal BER activity, which is critical in maintaining a low germline mutant frequency. Notably, spermatogenic cells respond differently than somatic cells to Pol haploinsufficiency.
  • The spontaneous mutant frequency for mixed spermatogenic cells prepared from Pol heterozygous mice was significantly greater than that of wild-type controls, but no significant effect was found among the somatic tissues tested. Results shown in the paper demonstrate that normal Pol abundance is necessary for normal BER activity, which is critical in maintaining a low germline mutant frequency. Notably, spermatogenic cells respond differently than somatic cells to Pol haploinsufficiency. (en)
Title
  • Mutagenesis Is Elevated in Male Germ Cells Obtained from DNA Polymerase-beta Heterozygous Mice
  • Mutagenesis Is Elevated in Male Germ Cells Obtained from DNA Polymerase-beta Heterozygous Mice (en)
skos:prefLabel
  • Mutagenesis Is Elevated in Male Germ Cells Obtained from DNA Polymerase-beta Heterozygous Mice
  • Mutagenesis Is Elevated in Male Germ Cells Obtained from DNA Polymerase-beta Heterozygous Mice (en)
skos:notation
  • RIV/68378041:_____/08:00338213!RIV10-AV0-68378041
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 381262
http://linked.open...ai/riv/idVysledku
  • RIV/68378041:_____/08:00338213
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • base excision repair; DNA repair; gamete biology (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [17325AEAF259]
http://linked.open...i/riv/nazevZdroje
  • Biology of Reproduction
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 79
http://linked.open...iv/tvurceVysledku
  • Rotrekl, Vladimír
  • Walter, Ch. A.
  • Allen, D.
  • Herbert, D. C.
  • McMahan, C. A.
  • Sobol, R. W.
  • Wilson, S. H.
http://linked.open...ain/vavai/riv/wos
  • 000260321300005
http://linked.open...n/vavai/riv/zamer
issn
  • 0006-3363
number of pages
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