About: Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer

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About: Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Jednonukleotidový polymorfizmus rs3802842 na 11q23.1 byl nedávno publikován jako asociovaný s rizikem vzniku CRC. Naším cílem bylo tuto asociaci prozkoumat do detailů v 8 různych case-control sériích sestávajících se ze 10,368 pacientů a 10,457 zdravých jedinců. Zaznamenali jsme signifikantní asociaci mezi C alelou rs3802842 a rizikem vzniku CRC s vyšší frekvencí C alely v rektální části tlustého střeva v porovnání se samotným tlustým střevem. (cs) The common single nucleotide polymorphism (SNP) rs3802842 at 11q23.1 has recently been reported to be associated with risk of colorectal cancer (CRC). To examine this association in detail we genotyped rs3802842 in eight independent case-control series comprising a total of 10,638 cases and 10,457 healthy individuals. A significant association between the C allele of rs3802842 and CRC risk was found (per allele OR =1.17; 95% confidence interval [CI]: 1.12-1.22; P=1.08 x 10(-12)) with the risk allele more frequent in rectal than colonic disease (P=0.02). The common single nucleotide polymorphism (SNP) rs3802842 at 11q23.1 has recently been reported to be associated with risk of colorectal cancer (CRC). To examine this association in detail we genotyped rs3802842 in eight independent case-control series comprising a total of 10,638 cases and 10,457 healthy individuals. A significant association between the C allele of rs3802842 and CRC risk was found (per allele OR =1.17; 95% confidence interval [CI]: 1.12-1.22; P=1.08 x 10(-12)) with the risk allele more frequent in rectal than colonic disease (P=0.02). (en)
Title	Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer (en) Upřesnění vlivu 11q23.1 variace ve vztahu k riziku vzniku CRC (cs)
skos:prefLabel	Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer (en) Upřesnění vlivu 11q23.1 variace ve vztahu k riziku vzniku CRC (cs)
skos:notation	RIV/68378041:_____/08:00314379!RIV09-AV0-68378041
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA310/07/1430), Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika	23
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Vodička, Pavel Naccarati, Alessio
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	391886
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/08:00314379
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Polymorphism; CRC (en)
http://linked.open.../riv/klicoveSlovo	CRC Polymorphism
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[85231C953F5A]
http://linked.open...i/riv/nazevZdroje	Human Molecular Genetics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	59 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular and genetic characteristics of sporadic colorectal cancer in the Czech Republic.
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	17
http://linked.open...iv/tvurceVysledku	Försti, A. Hemminki, K. Naccarati, Alessio Vodička, Pavel Carvajal-Carmona, L. Ho, J. W. C. Lipton, L. Morreau, H. Wijnen, J. T. van Wezel, T. Sullivan, K. Cazier, J. B. Houlston, R. S. Gorman, M. Aaltonen, L. Domingo, E. Broderick, P. Penegar, S. Tomlinson, I. P. M. Kerr, D. Giles, G. G. Martin, L. Agúndez, J. A. G. Barclay, E. Caldés, T. Chandler, I. Cheng, K. K. Fielding, S. Gray, R. Hopper, J. L. Howarth, K. Jäger, E. Karhu, A. Kemp, Z. Ladero, J. M. Lubbe, S. Lucassen, A. Luk, J. Maher, E. R. Niittymäki, I. Peto, J. Pittman, A. M. Qureshi, M. Rowan, A. Sham, P. C. Southey, M. C. Spain, S. Thomas, H. Tuupanene, S. Vijayakrishnan, J. Webb, E. Wood, W. de la Hoya, M. Walther, A. Bishop, T. Di-Bernardo, M. Evans, G. Price, A. Twiss, P.
http://linked.open...ain/vavai/riv/wos	260980800010
http://linked.open...n/vavai/riv/zamer	New biotechnologies, nanomaterials and stem cells for use in regenerative medicine
issn	0964-6906
number of pages	8 (xsd:int)

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