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Description
| - Micro-RNA (miRNAs) mají schopnost se vázat na 3´konce mRNA (UTRs) a modifikovat její translaci. Regulace pomocí miRNA může být ovlivněná polymorfismem v 3´UTR oblastech. Předpokládáme, že polymorfizmy v miRNA vážících se oblastech sehrávají roli při individuální vnímavosti na riziko vzniku rakoviny. V předkládané studii jsme analyzovali 3´UTR oblasti u 104 kandidátních genů pro kolorektální karcinom. (cs)
- Micro-RNAs (miRNAs) can bind to the 3' untranslated regions (UTRs) of messenger RNAs and interfere with their translation. Furthermore, miRNA regulation may be affected by polymorphisms on the 3' UTRs. We hypothesize that common polymorphisms within miRNA-target binding sites could play a role in the individual risk of cancer. In the present study, we selected and analysed the 3' UTRs of 104 genes candidate for colorectal cancer.
- Micro-RNAs (miRNAs) can bind to the 3' untranslated regions (UTRs) of messenger RNAs and interfere with their translation. Furthermore, miRNA regulation may be affected by polymorphisms on the 3' UTRs. We hypothesize that common polymorphisms within miRNA-target binding sites could play a role in the individual risk of cancer. In the present study, we selected and analysed the 3' UTRs of 104 genes candidate for colorectal cancer. (en)
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Title
| - Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer
- Polymorfizmy micro-RNA vazebních oblastí ve vztahu k riziku vzniku kolorektálního karcinomu. (cs)
- Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer (en)
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skos:prefLabel
| - Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer
- Polymorfizmy micro-RNA vazebních oblastí ve vztahu k riziku vzniku kolorektálního karcinomu. (cs)
- Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer (en)
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skos:notation
| - RIV/68378041:_____/08:00306350!RIV08-AV0-68378041
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA310/05/2626), P(GA310/07/1430), Z(AV0Z50390703)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378041:_____/08:00306350
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Colorectal cancer; Messenger RNA; Micro-RNA (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Canzian, F.
- Försti, A.
- Hemminki, K.
- Naccarati, Alessio
- Novotný, J.
- Pardini, Barbara
- Vodička, Pavel
- Vodičková, Ludmila
- Gemignani, F.
- Landi, D.
- Landi, S.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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