About: In vitro genotoxicity of PAH mixtures and organic extract from urban air particles. Part II: Human cell lines

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Two principal aims of this study were to find a relevant human derived cell line to investigate the genotoxic potential of PAH-containing complex mixtures and to use this cell system for the analysis of DNA adduct forming activity of organic compounds bound onto PM10 particles collected in 3 European cities. The results suggest that HepG2 cells have metabolic capacity for PAHs similar to human hepatocytes and, among the three cell lines tested in this study, they represent the best in vitro model to test genotoxic potential of complex mixtures containing PAHs. Two principal aims of this study were to find a relevant human derived cell line to investigate the genotoxic potential of PAH-containing complex mixtures and to use this cell system for the analysis of DNA adduct forming activity of organic compounds bound onto PM10 particles collected in 3 European cities. The results suggest that HepG2 cells have metabolic capacity for PAHs similar to human hepatocytes and, among the three cell lines tested in this study, they represent the best in vitro model to test genotoxic potential of complex mixtures containing PAHs. (en)
Title	In vitro genotoxicity of PAH mixtures and organic extract from urban air particles. Part II: Human cell lines In vitro genotoxicity of PAH mixtures and organic extract from urban air particles. Part II: Human cell lines (en)
skos:prefLabel	In vitro genotoxicity of PAH mixtures and organic extract from urban air particles. Part II: Human cell lines In vitro genotoxicity of PAH mixtures and organic extract from urban air particles. Part II: Human cell lines (en)
skos:notation	RIV/68378041:_____/07:00342052!RIV10-MZP-68378041
http://linked.open...avai/riv/aktivita	P R Z
http://linked.open...avai/riv/aktivity	P(SI/340/2/00), P(SL/740/5/03), R, Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Sevastyanova, Oksana Šrám, Radim Topinka, Jan Binková, Blanka Nováková, Zuzana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	425860
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/07:00342052
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA adducts; 32P-postlabeling; complex mixtures (en)
http://linked.open.../riv/klicoveSlovo	32P-postlabeling DNA adducts complex mixtures
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[3FA69D6A09CB]
http://linked.open...i/riv/nazevZdroje	Mutation Research
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Impact of complex mixtures in polluted air on the health of risk population groups( Program Air pollution and health) Air pollution and health protection
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	620
http://linked.open...iv/tvurceVysledku	Binková, Blanka Nováková, Zuzana Topinka, Jan Šrám, Radim Farmer, P. B. Sevastyanova, Oksana Kalina, I. Popov, T.
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	0027-5107
number of pages	12 (xsd:int)

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