About: Ivermectin potentiates ATP-induced ion currents in cortical neurones: Evidence for functional expression of P2X4 receptors?

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Studovali jsme vliv antiparazitické látky ivermektinu na ATP- a alfa,beta-methylen-ATP (alpha,beta-me-ATP)- aktivované proudy v akutně izolovaných neuronech v řezech somatosenzorické kůry potkana typu CBL57 starého 17-22 dní. Naše výsledky prokázaly funkční expresi P2X4 receptorů v korových neuronech a jejich účast v purinergním synaptickém přenosu v mozkové kůře. (cs) We examined the effects of an antiparasitic agent ivermectin on ATP- and alpha,beta-methylene-ATP (alpha,beta-me-ATP)-activated currents in neurones acutely isolated from slices of somato-sensory cortex of 17-22 days old CBL57 mice. These results indicate functional expression of P2X4 receptors in cortical neurones and their involvement in purinergic synaptic transmission in cortex. We examined the effects of an antiparasitic agent ivermectin on ATP- and alpha,beta-methylene-ATP (alpha,beta-me-ATP)-activated currents in neurones acutely isolated from slices of somato-sensory cortex of 17-22 days old CBL57 mice. These results indicate functional expression of P2X4 receptors in cortical neurones and their involvement in purinergic synaptic transmission in cortex. (en)
Title	Ivermectin potentiates ATP-induced ion currents in cortical neurones: Evidence for functional expression of P2X4 receptors? Ivermectin potencuje iontové proudy vyvolané ATP v korových neuronech: důkaz pro funkční expresi P2X4 receptorů? (cs) Ivermectin potentiates ATP-induced ion currents in cortical neurones: Evidence for functional expression of P2X4 receptors? (en)
skos:prefLabel	Ivermectin potentiates ATP-induced ion currents in cortical neurones: Evidence for functional expression of P2X4 receptors? Ivermectin potencuje iontové proudy vyvolané ATP v korových neuronech: důkaz pro funkční expresi P2X4 receptorů? (cs) Ivermectin potentiates ATP-induced ion currents in cortical neurones: Evidence for functional expression of P2X4 receptors? (en)
skos:notation	RIV/68378041:_____/07:00096390!RIV08-AV0-68378041
http://linked.open.../vavai/riv/strany	158;162
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Verkhratsky, Alexei
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	427703
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/07:00096390
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Invermectin; Cortex; Purinoceptor (en)
http://linked.open.../riv/klicoveSlovo	Purinoceptor Invermectin Cortex
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[818D9FE156A4]
http://linked.open...i/riv/nazevZdroje	Neuroscience Letters
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	421
http://linked.open...iv/tvurceVysledku	Lalo, U. Pankratov, Y. Verkhratsky, Alexei
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	0304-3940
number of pages	5 (xsd:int)

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