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Description
  • Pro-neurální účinek leukemického inhibičního faktoru, cytokinu, který zesiluje neurální diferenciaci indukovanou retinovou kyselinou, a částečně i účinek kyseliny retinové, jsou zrušeny inhibicí JAK2->STAT3 signální dráhy. Naopak inhibice MEK1->ERK signální dráhy nevykazuje žádný účinek. Z výsledků vyplývá, že účinek leukemického inhibičního faktoru a ostatních indukčních faktorů neurální diferenciace může být způsobena STAT3 signální dráhou. (cs)
  • The pro-neural effects of LIF, a cytokine that potentiated retinoic acid-induced neural differentiation, and partially also effects of retinoic acid are abolished by inhibition of the JAK2->STAT3 signalling pathway. In contrast, inhibition of the MEK1->ERK signalling pathway does not exhibit any effect. Data suggest the action of LIF and other neuro-differentiation-inducing factors may be mediated by the STAT3 signalling pathway.
  • The pro-neural effects of LIF, a cytokine that potentiated retinoic acid-induced neural differentiation, and partially also effects of retinoic acid are abolished by inhibition of the JAK2->STAT3 signalling pathway. In contrast, inhibition of the MEK1->ERK signalling pathway does not exhibit any effect. Data suggest the action of LIF and other neuro-differentiation-inducing factors may be mediated by the STAT3 signalling pathway. (en)
Title
  • Neural differentiation potentiated by the leukaemia inhibitory factor through STAT3 signalling in mouse embryonal carcinoma cells
  • Neural differentiation potentiated by the leukaemia inhibitory factor through STAT3 signalling in mouse embryonal carcinoma cells (en)
  • Neurální diferenciace zesílená leukemickým inhibičním faktorem skrze signální dráhu STAT3 v myších embryonálních rakovinných buňkách (cs)
skos:prefLabel
  • Neural differentiation potentiated by the leukaemia inhibitory factor through STAT3 signalling in mouse embryonal carcinoma cells
  • Neural differentiation potentiated by the leukaemia inhibitory factor through STAT3 signalling in mouse embryonal carcinoma cells (en)
  • Neurální diferenciace zesílená leukemickým inhibičním faktorem skrze signální dráhu STAT3 v myších embryonálních rakovinných buňkách (cs)
skos:notation
  • RIV/68378041:_____/07:00085980!RIV08-AV0-68378041
http://linked.open.../vavai/riv/strany
  • 157;163
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50040507), Z(AV0Z50040702), Z(AV0Z50390512), Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 436982
http://linked.open...ai/riv/idVysledku
  • RIV/68378041:_____/07:00085980
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • neural differentiation; leukaemia inhibitory factor; STAT3 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [34285F7BFB11]
http://linked.open...i/riv/nazevZdroje
  • Folia Biologica
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 53
http://linked.open...iv/tvurceVysledku
  • Dvořák, Petr
  • Hampl, Aleš
  • Horváth, Viktor
  • Kozubík, Alois
  • Kubala, Lukáš
  • Pacherník, J.
http://linked.open...n/vavai/riv/zamer
issn
  • 0015-5500
number of pages
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