About: 7-Alkylguanine adduct levels in urine, lungs and liver of mice exposed to styrene by inhalation     Goto   Sponge   NotDistinct   Permalink

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  • This study describes urinary excretion of two nucleobase adducts derived from styrene 7,8-oxide as well as a formation of 7-SO-guanine adducts in lungs and liver of NMRI mice exposed to styrene by inhalation. Strikingly higher excretion of both isomeric nucleobase adducts in the first day of exposure was reecorded, while the daily excretion of nucleobase adducts in following time intervals reached the steady-state level. A comparison of 7-alkylguanines excreted in urine with 7-SO-guanines in lungs revealed that persisting 7-SO-guanine DNA adducts in lungs account for about 0.5% ot the total alkylation at N7 of guanine. The total styrene-specific 7-guanine alkylation accounts for about 1.0x10-5% of the total styrene uptake.
  • This study describes urinary excretion of two nucleobase adducts derived from styrene 7,8-oxide as well as a formation of 7-SO-guanine adducts in lungs and liver of NMRI mice exposed to styrene by inhalation. Strikingly higher excretion of both isomeric nucleobase adducts in the first day of exposure was reecorded, while the daily excretion of nucleobase adducts in following time intervals reached the steady-state level. A comparison of 7-alkylguanines excreted in urine with 7-SO-guanines in lungs revealed that persisting 7-SO-guanine DNA adducts in lungs account for about 0.5% ot the total alkylation at N7 of guanine. The total styrene-specific 7-guanine alkylation accounts for about 1.0x10-5% of the total styrene uptake. (en)
  • Studie pojednává o vylučování dvou nukleobázových adduktů, odvozených od styrén 7,8-oxidu, močí jakož i o tvorbě 7-SO-guaninových aduktů v plicích a játrech NMRI myší po inhalační expozici styrénu. Významně vyšší vylučování obou isomerních nukleobázových aduktů bylo pozorováno po prvním dnu expozice, zatímco vylučování nukleobázových aduktů v dalších intervalech bylo v dynamické rovnováze. Srovnání hladin 7-alkylguaninů vylučovaných močí s hladinami 7-SO-guaninů v plicích odhalilo, že persistující 7-SO-guaninové DNA adukty v plicích představují 0.5% celkové alkylace na N7 pozici guaninu. Celková alkylace styrénem na N7 pozici guaninu pak činí 1.0x10-5% celkového příjmu styrénu organismem. (cs)
Title
  • 7-Alkylguanine adduct levels in urine, lungs and liver of mice exposed to styrene by inhalation
  • Hladiny 7-alkylguaninových aduktů v moči, plicích a játrech myší po inhalační expozici styrénu (cs)
  • 7-Alkylguanine adduct levels in urine, lungs and liver of mice exposed to styrene by inhalation (en)
skos:prefLabel
  • 7-Alkylguanine adduct levels in urine, lungs and liver of mice exposed to styrene by inhalation
  • Hladiny 7-alkylguaninových aduktů v moči, plicích a játrech myší po inhalační expozici styrénu (cs)
  • 7-Alkylguanine adduct levels in urine, lungs and liver of mice exposed to styrene by inhalation (en)
skos:notation
  • RIV/68378041:_____/06:00043867!RIV07-AV0-68378041
http://linked.open.../vavai/riv/strany
  • 1;8
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA310/03/0437), Z(AV0Z5039906)
http://linked.open...iv/cisloPeriodika
  • 1-2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 510723
http://linked.open...ai/riv/idVysledku
  • RIV/68378041:_____/06:00043867
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • 7-Alkylguanine; Styrene (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [3E91A9254968]
http://linked.open...i/riv/nazevZdroje
  • Toxicology and Applied Pharmacology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 210
http://linked.open...iv/tvurceVysledku
  • Hemminki, K.
  • Vodička, Pavel
  • Vodičková, Ludmila
  • Novák, I.
  • Linhart, I.
  • Koskinen, M.
http://linked.open...n/vavai/riv/zamer
issn
  • 0041-008X
number of pages
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