About: FGF2 inhibits proliferation and alters the cartilage-like phenotype of RCS cells

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	It was shown that treatment with FGF2 induced growth arrest in the G1 phase and partial de-differentiation of RCS chondrocytes. FGF2 also activated PLCg, protein kinase B, and Erk and p38 MAP kinases. Inhibition of FGFR3 and MEK1/2 antagonized FGF-2-mediated growth arrest. Expression of a dominant negative Ras resulted in a partial reversal of growth inhibition, while expression of constitutively activated Ras led to Erk-dependent growth arrest. At the molecular level, FGF2-induced growth arrest was followed by changes in cell cycle regulating complexes It was shown that treatment with FGF2 induced growth arrest in the G1 phase and partial de-differentiation of RCS chondrocytes. FGF2 also activated PLCg, protein kinase B, and Erk and p38 MAP kinases. Inhibition of FGFR3 and MEK1/2 antagonized FGF-2-mediated growth arrest. Expression of a dominant negative Ras resulted in a partial reversal of growth inhibition, while expression of constitutively activated Ras led to Erk-dependent growth arrest. At the molecular level, FGF2-induced growth arrest was followed by changes in cell cycle regulating complexes (en) Bylo prokázáno, že FGF2 indukuje zástavu růstu v G1 fázi buněčného cyklu a rediferenciaci chodrocytů RCS. FGF2 u těchto buněk také aktivuje PLCg, protein kinázu B, a Erk a p38 MAP kinázy. Inhibice FGFR3 a MEK1/2 u RCS buněk působí antagonicky na růstovou inhibici indukovanou FGF2. Ukázalo se, že exprese dominantně negativního Ras, částečně snižuje inhibici růstu vyvolanou FGF2. Zárověn, exprese konstitutivně aktivního Ras inhibuje růst těchto buněk v závislosti na aktivitě Erk. Současně s inhibicí růstu RCS buněk byly detekovány i změny v expresi a asociaci regulátorů buněnčného cyklu (cs)
Title	FGF2 inhibits proliferation and alters the cartilage-like phenotype of RCS cells FGF2 inhibuje proliferaci a mění chrupavkovitý fenotyp buněk RCS (cs) FGF2 inhibits proliferation and alters the cartilage-like phenotype of RCS cells (en)
skos:prefLabel	FGF2 inhibits proliferation and alters the cartilage-like phenotype of RCS cells FGF2 inhibuje proliferaci a mění chrupavkovitý fenotyp buněk RCS (cs) FGF2 inhibits proliferation and alters the cartilage-like phenotype of RCS cells (en)
skos:notation	RIV/68378041:_____/04:00101010!RIV/2005/MSM/A19005/N
http://linked.open.../vavai/riv/strany	152;164
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LN00A065), Z(AV0Z5039906)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Hampl, Aleš Bryja, Vítězslav Pacherník, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	564314
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/04:00101010
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	fibroblast growth factor (en)
http://linked.open.../riv/klicoveSlovo	fibroblast growth factor
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[A4DACFF1EC15]
http://linked.open...i/riv/nazevZdroje	Experimental Cell Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Cell Therapy and Tissue Repair
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	297
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Hampl, Aleš Pacherník, Jiří Krejčí, P. Wilcox, W. R. Mekikian, P. Pogue, R.
http://linked.open...n/vavai/riv/zamer	The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy
issn	0014-4827
number of pages	13 (xsd:int)

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