About: Lipoxygenease inhibitors enhance tumor suppressive effects of Jun proteins on v-myb-transformed monoblasts BM2.

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About: Lipoxygenease inhibitors enhance tumor suppressive effects of Jun proteins on v-myb-transformed monoblasts BM2. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this study lipoxygenase inhibitors were used to study the role of arachidonic acid metabolism in regulation of proliferation and apoptosis of chicken monoblasts BM2 and its functional interaction with Jun proteins. It was demonstrated that lipoxygenase inhibitors further enforce tumor suppresive capabilities of Jun proteins by inducing either more efficient cell cycle block and/or apoptosis in BM2 cells. This suggests that there is a crosstalk between the lipoxygenase- and Jun-directed pathways in regulation of proliferation and differentiation of leukemic cells. In this study lipoxygenase inhibitors were used to study the role of arachidonic acid metabolism in regulation of proliferation and apoptosis of chicken monoblasts BM2 and its functional interaction with Jun proteins. It was demonstrated that lipoxygenase inhibitors further enforce tumor suppresive capabilities of Jun proteins by inducing either more efficient cell cycle block and/or apoptosis in BM2 cells. This suggests that there is a crosstalk between the lipoxygenase- and Jun-directed pathways in regulation of proliferation and differentiation of leukemic cells. (en)
Title	Lipoxygenease inhibitors enhance tumor suppressive effects of Jun proteins on v-myb-transformed monoblasts BM2. Lipoxygenease inhibitors enhance tumor suppressive effects of Jun proteins on v-myb-transformed monoblasts BM2. (en)
skos:prefLabel	Lipoxygenease inhibitors enhance tumor suppressive effects of Jun proteins on v-myb-transformed monoblasts BM2. Lipoxygenease inhibitors enhance tumor suppressive effects of Jun proteins on v-myb-transformed monoblasts BM2. (en)
skos:notation	RIV/68378041:_____/03:19033062!RIV/2004/AV0/A19004/N
http://linked.open.../vavai/riv/strany	131;145
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/01/0040), P(GA524/03/0766), Z(AV0Z5039906)
http://linked.open...iv/cisloPeriodika	N/A
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Bryja, Vítězslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	613661
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/03:19033062
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hematopoiesis (en)
http://linked.open.../riv/klicoveSlovo	hematopoiesis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1E90EABB5513]
http://linked.open...i/riv/nazevZdroje	Prastaglandis & other lipid mediators
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	The Role of Fos and Jun proteins in RA-driven monocytic differentiation Modulation of proliferation, differentiation and apoptosis of hemopoietic cells - interactions of cytokines, drugs and lipid nutrition compounds
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	72
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Sedláček, J. Šmarda, J. Pacherník, J. Hofmanová, J. Kozubík, A. Souček, K. Ševčíková, S. Zahradníčková, E.
http://linked.open...n/vavai/riv/zamer	The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy
issn	1098-8823
number of pages	15 (xsd:int)

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