About: Cyclin D-cdk6 complex is targeted by p21WAF in growth-arrested lymphoma cells.

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About: Cyclin D-cdk6 complex is targeted by p21WAF in growth-arrested lymphoma cells. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The kinase activity of cdk2, cdk4, and cdk6 was significantly reduced and hypophosphorylation of pRb on serine 795 (S795) and threonine 373 (T373) was observed. Both cdk4 and cdk6 were notably dissociated from cyclin D co-factors, while cyclin E-cdk2 complexes remained coupled in TGF 1-treated cells. TGF 1-induced growth arrest was associated with notably increased binding of p21WAF1 to cdk4 and cdk6. The kinase activity of cdk2, cdk4, and cdk6 was significantly reduced and hypophosphorylation of pRb on serine 795 (S795) and threonine 373 (T373) was observed. Both cdk4 and cdk6 were notably dissociated from cyclin D co-factors, while cyclin E-cdk2 complexes remained coupled in TGF 1-treated cells. TGF 1-induced growth arrest was associated with notably increased binding of p21WAF1 to cdk4 and cdk6. (en)
Title	Cyclin D-cdk6 complex is targeted by p21WAF in growth-arrested lymphoma cells. Cyclin D-cdk6 complex is targeted by p21WAF in growth-arrested lymphoma cells. (en)
skos:prefLabel	Cyclin D-cdk6 complex is targeted by p21WAF in growth-arrested lymphoma cells. Cyclin D-cdk6 complex is targeted by p21WAF in growth-arrested lymphoma cells. (en)
skos:notation	RIV/68378041:_____/02:19023085!RIV/2003/GA0/A19003/N
http://linked.open.../vavai/riv/strany	49;56
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA304/01/0564), Z(AV0Z5039906), Z(MSM 111100003)
http://linked.open...iv/cisloPeriodika	N/A
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Müller, Julius Djaborkhel, Rashed Raška, Ivan Nagy, Alexander Tvrdík, Daniel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	642017
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/02:19023085
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cyclin-dependent kinase; follicular lymphoma; retinoblastoma protein (en)
http://linked.open.../riv/klicoveSlovo	retinoblastoma protein follicular lymphoma cyclin-dependent kinase
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B36069F40913]
http://linked.open...i/riv/nazevZdroje	Journal of Structural Biology
http://linked.open...in/vavai/riv/obor	EA
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	The mechanism of inhibitory action imposed on cyclin-dependenz kinases in malignant human B lymphocytes
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	140
http://linked.open...iv/tvurceVysledku	Eckschlager, T. Raška, Ivan Tvrdík, Daniel Müller, Julius Djaborkhel, Rashed Nagy, Alexandr
http://linked.open...n/vavai/riv/zamer	The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111100003
issn	1047-8477
number of pages	8 (xsd:int)

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