About: Allelic and haplotype frequencies of the p53 polymorphisms in brain tumor patients.

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About: Allelic and haplotype frequencies of the p53 polymorphisms in brain tumor patients. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The polymorphisms of the tumor suppressor gene p53 in exon 4 (p53 BstUI) and in intron 6 (p53 MspI) have been suggested to be associated with the genetically determined susceptibility in diverse types of human cancer. In our hospital-based case-control study, we examined the allele and genotype incidence of these polymorphisms as well as their haplotype combinations in 60 brain tumor patients (27 males and 33 females) and 183 controls without malignancies. The genotype characteristics were determined by the PCR-based RFLP method using DNA extracted from peripheral blood. In this study we show that the p53 BstUI and the p53 MspI polymorphisms are not associated with increased risk of brain tumors. Thus, we conclude that the p53 BstUI and the p53 MspI polymorphic sites within the tumor suppressor gene p53 do not represent genetic determinants of susceptibility to brain tumors. The polymorphisms of the tumor suppressor gene p53 in exon 4 (p53 BstUI) and in intron 6 (p53 MspI) have been suggested to be associated with the genetically determined susceptibility in diverse types of human cancer. In our hospital-based case-control study, we examined the allele and genotype incidence of these polymorphisms as well as their haplotype combinations in 60 brain tumor patients (27 males and 33 females) and 183 controls without malignancies. The genotype characteristics were determined by the PCR-based RFLP method using DNA extracted from peripheral blood. In this study we show that the p53 BstUI and the p53 MspI polymorphisms are not associated with increased risk of brain tumors. Thus, we conclude that the p53 BstUI and the p53 MspI polymorphic sites within the tumor suppressor gene p53 do not represent genetic determinants of susceptibility to brain tumors. (en)
Title	Allelic and haplotype frequencies of the p53 polymorphisms in brain tumor patients. Allelic and haplotype frequencies of the p53 polymorphisms in brain tumor patients. (en)
skos:prefLabel	Allelic and haplotype frequencies of the p53 polymorphisms in brain tumor patients. Allelic and haplotype frequencies of the p53 polymorphisms in brain tumor patients. (en)
skos:notation	RIV/68378041:_____/02:19023023!RIV/2003/AV0/A19003/N
http://linked.open.../vavai/riv/strany	59;64
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(SI/340/1/97), Z(AV0Z5039906)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Biroš, Erik
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	637804
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/02:19023023
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Brain tumor; Susceptibility; p53 (en)
http://linked.open.../riv/klicoveSlovo	Brain tumor p53 Susceptibility
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[AEC7896D1489]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Impact of environmental pollution on the human health in the Teplice region - Teplice Program II
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	51
http://linked.open...iv/tvurceVysledku	Šalagovič, J. Kalina, I. Biroš, Erik Bogyiová, E. Kohút, A. Šulla, I.
http://linked.open...n/vavai/riv/zamer	The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy
issn	0862-8408
number of pages	6 (xsd:int)

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