About: mtDNA segregation in heteroplasmic tissues is common in vivo and modulated by haplotype differences and developmental stage

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: mtDNA segregation in heteroplasmic tissues is common in vivo and modulated by haplotype differences and developmental stage Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The dynamics by which mitochondrial DNA (mtDNA) evolves within organisms are still poorly understood, despite the fact that inheritance and proliferation of mutated mtDNA cause fatal and incurable diseases. When two mtDNA haplotypes are present in a cell, it is usually assumed that segregation (the proliferation of one haplotype over another) is negligible. We challenge this assumption by showing that segregation depends on the genetic distance between haplotypes. We provide evidence by creating four mouse models containing mtDNA haplotype pairs of varying diversity. We find tissue-specific segregation in all models over a wide range of tissues. Key findings are segregation in postmitotic tissues (important for disease models) and segregation covering all developmental stages from prenatal to old age. We identify four dynamic regimes of mtDNA segregation. Our findings suggest potential complications for therapies in human populations: we propose %22haplotype matching%22 as an approach to avoid these issues. The dynamics by which mitochondrial DNA (mtDNA) evolves within organisms are still poorly understood, despite the fact that inheritance and proliferation of mutated mtDNA cause fatal and incurable diseases. When two mtDNA haplotypes are present in a cell, it is usually assumed that segregation (the proliferation of one haplotype over another) is negligible. We challenge this assumption by showing that segregation depends on the genetic distance between haplotypes. We provide evidence by creating four mouse models containing mtDNA haplotype pairs of varying diversity. We find tissue-specific segregation in all models over a wide range of tissues. Key findings are segregation in postmitotic tissues (important for disease models) and segregation covering all developmental stages from prenatal to old age. We identify four dynamic regimes of mtDNA segregation. Our findings suggest potential complications for therapies in human populations: we propose %22haplotype matching%22 as an approach to avoid these issues. (en)
Title	mtDNA segregation in heteroplasmic tissues is common in vivo and modulated by haplotype differences and developmental stage mtDNA segregation in heteroplasmic tissues is common in vivo and modulated by haplotype differences and developmental stage (en)
skos:prefLabel	mtDNA segregation in heteroplasmic tissues is common in vivo and modulated by haplotype differences and developmental stage mtDNA segregation in heteroplasmic tissues is common in vivo and modulated by haplotype differences and developmental stage (en)
skos:notation	RIV/68081766:_____/14:00429253!RIV15-AV0-68081766
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Piálek, Jaroslav Albrechtová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav biologie obratlovců AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	30908
http://linked.open...ai/riv/idVysledku	RIV/68081766:_____/14:00429253
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mitochondrial DNA; mice; transmission; evolution; selection; mutation; replication; variants; growth; blood (en)
http://linked.open.../riv/klicoveSlovo	replication evolution growth mitochondrial DNA selection mice mutation transmission blood variants
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BD1EBD128A3F]
http://linked.open...i/riv/nazevZdroje	Cell Reports
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	17 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Albrechtová, Jana Piálek, Jaroslav Klein, D. Rülicke, T. Blattner, M. Brem, G. Burgstaller, J. P. Futschik, A. Gülly, C. Johnston, I. G. Jones, N. S. Kolbe, T. Mayrhofer, C. Poulton, J. Sabitzer, S. Steinborn, R. Vogl, C.
http://linked.open...ain/vavai/riv/wos	000338325400027
issn	2211-1247
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.celrep.2014.05.020

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software